Hans‐Georg Beisel

Orion Corporation (Finland) — Finland

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index655citations17works0.02yr avg
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Research Topics

Venomous Animal Envenomation and Studies(3), Invertebrate Immune Response Mechanisms(3), Protein Kinase Regulation and GTPase Signaling(2), Lipoproteins and Cardiovascular Health(2), Cellular transport and secretion(2)

Publications17 total

Abstract 6179: Comparative study of Polθ helicase and polymerase inhibitor biochemical and cellular potency
Cancer Research·2023
Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A<sub>2</sub> Type X (sPLA<sub>2</sub>-X) Inhibitors
ACS Medicinal Chemistry Letters·2018· 12 citedOpen Access
Design of Selective sPLA<sub>2</sub>-X Inhibitor (−)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1<i>H</i>-indol-1-yl]pyridine-2-yl}propanoic Acid
ACS Medicinal Chemistry Letters·2018· 8 citedOpen Access
Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation—Structure‐Based Hit Evaluation and Chemistry Exploration
ChemMedChem·2016· 15 cited
Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9
Protein Engineering Design and Selection·2015· 9 cited
Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design
PLoS ONE·2015· 37 citedOpen Access
Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening
Bioorganic & Medicinal Chemistry Letters·2014· 19 citedOpen Access
Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design
2014
In Silico and NMR Identification of Inhibitors of the IGF-I and IGF-Binding Protein-5 Interaction
Journal of Medicinal Chemistry·2002· 8 citedOpen Access
The 2.0-Å crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems
Proceedings of the National Academy of Sciences·2001· 142 citedOpen Access
Complex of IGFBP-5 with IGF-I
2001
Role of Tachylectins in Host Defense of the Japanese Horseshoe Crab Tachypleus Tridentatus
Advances in experimental medicine and biology·2001· 9 cited
Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)
1999
Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus
The EMBO Journal·1999· 170 citedOpen Access
Crystal structure of the hydrogenase maturating endopeptidase HYBD from Escherichia coli
Journal of Molecular Biology·1999· 96 cited
Structure of dihydrodipicolinate synthase of Nicotiana sylvestris reveals novel quaternary structure
Journal of Molecular Biology·1997· 86 cited
Horseshoe Grab Coagulogen Is an Invertebrate Protein with a Nerve Growth Factor-Like Domain
Biological Chemistry·1997· 44 cited

Frequent Co-authors

Jenny Sandmark(5), Wolfram Bode(4), Robert Huber(4), Robert Roth(4), Linda Öster(4), Mattias Rohman(4), Sadaaki Iwanaga(3), David Karis(3), Wolfgang Knecht(3), Laurent Knerr(3), Tomas Åkerud(3), Shun-ichiro Kawabata(2), Ryoko Tsuda(2), Tatsushi Muta(2), Ola Fjellström(2), Sibel Akkaya(2), Karl M. Erixon(2), Ulrik Jurva(2), Viveca Nerme(2), Thomas Olsson(2)