Francesco Saverio Di Leva

University of Naples Federico II — Italy

Medicine · Health Sciences

30h-index2.3kcitations83works2.62yr avg
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Research Topics

Cell Adhesion Molecules Research(18), Drug Transport and Resistance Mechanisms(14), HIV/AIDS drug development and treatment(13), Advanced biosensing and bioanalysis techniques(9), Monoclonal and Polyclonal Antibodies Research(9)

Publications82 total

Coupling PD-L1 Inhibition and Lysosomal Degradation: Innovative Anti-PD-L1 Peptides for NSCLC Immunotherapy
Journal of Medicinal Chemistry·2026
From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1-Gs Complex
2026Open Access
Stereocontrolled Synthesis of α-Branched Tetrahydropyrans by a One-Pot-Two-Step Photobiocatalytic Cascade of Citronellol
Journal of Natural Products·2026
Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E
2025Open Access
Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells
International Journal of Molecular Sciences·2025Open Access
Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy
Journal of Chemical Information and Modeling·2025· 1 citedOpen Access
Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats
European Journal of Medicinal Chemistry·2025· 3 citedOpen Access
Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1
Cell Death Discovery·2025· 2 citedOpen Access
Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations
The Journal of Chemical Physics·2025· 1 cited
Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
Design, Synthesis and Characterization of Aryl Bis-Guanyl Hydrazones as Rna Binders of C9orf72 G4c2 Extended Repeats
SSRN Electronic Journal·2025Open Access
Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents
Journal of Medicinal Chemistry·2025· 6 cited
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination
Frontiers in Molecular Neuroscience·2024· 1 citedOpen Access
Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors
Communications Chemistry·2024· 14 citedOpen Access
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists
Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells
Journal of Medicinal Chemistry·2024· 11 cited
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors
Archiv der Pharmazie·2023· 3 citedOpen Access
Molecular View on the <i>i</i>RGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles
Journal of Chemical Information and Modeling·2023· 20 citedOpen Access
Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic
European Journal of Medicinal Chemistry·2023· 16 citedOpen Access
Microscopic View of the iRGD Peptide Binding Mechanism
2023Open Access
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Frequent Co-authors

Ettore Novellino(36), Luciana Marinelli(28), Sandro Cosconati(14), Vittorio Limongelli(13), Horst Kessler(13), Salvatore Di Maro(12), Angela Zampella(10), Stefano Fiorucci(10), Stefano Tomassi(10), Carmen Festa(7), Roberto Di Santo(7), Florian Reichart(7), Valentina Sepe(6), Udaya Kiran Marelli(6), Simona De Marino(6), Diego Brancaccio(6), Vincenzo Maria D’Amore(6), Barbara Renga(5), Angela Corona(5), Luca Pescatori(5)