Sarah L. Huszar

United States Military Academy — United States

Neuroscience · Life Sciences

12h-index620citations14works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(8), Receptor Mechanisms and Signaling(7), Cholinesterase and Neurodegenerative Diseases(4), Phosphodiesterase function and regulation(4), Neurotransmitter Receptor Influence on Behavior(3)

Publications14 total

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Journal of Medicinal Chemistry·2023· 37 citedOpen Access
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis
Bioorganic & Medicinal Chemistry Letters·2016· 9 citedOpen Access
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI
ACS Medicinal Chemistry Letters·2016· 9 citedOpen Access
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Bioorganic & Medicinal Chemistry Letters·2015· 26 citedOpen Access
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target
Neuropharmacology·2013· 93 cited
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Bioorganic & Medicinal Chemistry Letters·2012· 34 citedOpen Access
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey
Neuropharmacology·2012· 84 citedOpen Access
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats
Neuropharmacology·2010· 32 cited
Genetic and Pharmacological Evaluation of Cathepsin S in a Mouse Model of Asthma
American Journal of Respiratory Cell and Molecular Biology·2010· 47 cited
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor
ACS Medicinal Chemistry Letters·2010· 22 citedOpen Access
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Bioorganic & Medicinal Chemistry Letters·2010· 40 citedOpen Access
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?
Pharmacology Biochemistry and Behavior·2010· 77 cited
Combined administration of an mGlu2/3 receptor agonist and a 5-HT2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants
Psychopharmacology·2009· 29 cited
The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4 H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine
Journal of Pharmacology and Experimental Therapeutics·2008· 81 cited

Frequent Co-authors

Jason M. Uslaner(13), Sean M. Smith(7), Julie A. O’Brien(5), Brian C. Magliaro(5), Monika Kandebo(5), Marlene A. Jacobson(5), Christopher D. Cox(4), Joshua D. Vardigan(4), Izzat T. Raheem(4), Paul J. Coleman(4), John J. Renger(4), R. M. Garbaccio(4), M. E. Layton(4), Pete H. Hutson(4), Kerry L. Fillgrove(4), Cuyue Tang(4), Yuhsin Kuo(4), Peter H. Hutson(3), Lihang Yao(3), John D. Schreier(3)