Joshua D. Vardigan

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

12h-index561citations22works3.52yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuroscience and Neuropharmacology Research(10), Receptor Mechanisms and Signaling(8), Ion channel regulation and function(7), Pain Mechanisms and Treatments(5), Nicotinic Acetylcholine Receptors Study(5)

Publications22 total

Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors
Neurobiology of Pain·2025· 4 citedOpen Access
Preclinical evaluation of MK-8189: A novel phosphodiesterase 10A inhibitor for the treatment of schizophrenia
Journal of Pharmacology and Experimental Therapeutics·2024· 3 citedOpen Access
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Pain·2024· 4 citedOpen Access
2-Aminopyridines as Potent and Selective Na<sub>v</sub>1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
ACS Medicinal Chemistry Letters·2023· 7 citedOpen Access
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease
ACS Medicinal Chemistry Letters·2023· 11 citedOpen Access
Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose
Frontiers in Pharmacology·2021· 7 citedOpen Access
Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey
Neuropharmacology·2021· 19 cited
Na <sub>v</sub> 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Science Translational Medicine·2021· 20 cited
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate
Pharmaceutical Research·2020· 5 citedOpen Access
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator BNC375
Journal of Pharmacology and Experimental Therapeutics·2020· 16 citedOpen Access
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects
Journal of Pain Research·2018· 11 citedOpen Access
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease
Neurobiology of Aging·2017· 53 cited
Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity
Psychopharmacology·2016· 5 cited
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model
Behavioural Brain Research·2015· 44 cited
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey
Psychopharmacology·2014· 61 cited
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey
Neuropharmacology·2012· 84 citedOpen Access
The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task
Journal of Neurogenetics·2011· 52 cited
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats
Neuropharmacology·2010· 32 cited
T-Type Calcium Channel Antagonism Decreases Motivation for Nicotine and Blocks Nicotine- and Cue-Induced Reinstatement for a Response Previously Reinforced with Nicotine
Biological Psychiatry·2010· 14 cited
page 1 of 2Next →

Frequent Co-authors

Jason M. Uslaner(17), Darrell A. Henze(7), Sean M. Smith(6), Richard L. Kraus(6), Parul S. Pall(6), John J. Renger(5), Yuxing Li(5), Henry S. Lange(5), Sarah L. Huszar(4), Michael J. Breslin(4), Vanita Puri(4), Pete H. Hutson(4), Jeanine Ballard(4), Michelle K. Clements(4), Christopher S. Burgey(4), Andrea K. Houghton(4), Xiaoping Zhou(4), Christopher E. Cannon(3), Monika Kandebo(3), Lihang Yao(3)