Darrell A. Henze

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

36h-index9.7kcitations68works2.42yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(36), Neural dynamics and brain function(25), Memory and Neural Mechanisms(21), Ion channel regulation and function(11), Pain Mechanisms and Treatments(9)

Publications68 total

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity
2025· 1 citedOpen Access
Multi-omics profiles of chronic low back pain and fibromyalgia—Study protocol
PLoS ONE·2025· 1 citedOpen Access
Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors
Neurobiology of Pain·2025· 4 citedOpen Access
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Pain·2024· 4 citedOpen Access
Multi-Omics Profiles of Chronic Low Back Pain and Fibromyalgia - Study Protocol
2024· 2 citedOpen Access
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Channels·2022· 3 citedOpen Access
Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose
Frontiers in Pharmacology·2021· 7 citedOpen Access
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain
Journal of Medicinal Chemistry·2021· 21 citedOpen Access
Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey
Neuropharmacology·2021· 19 cited
Na <sub>v</sub> 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Science Translational Medicine·2021· 20 cited
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate
Pharmaceutical Research·2020· 5 citedOpen Access
Antinociceptive effects of potent, selective and brain penetrant muscarinic M4 positive allosteric modulators in rodent pain models
Brain Research·2020· 2 cited
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects
Journal of Pain Research·2018· 11 citedOpen Access
Characterization of non-active site TrkA selective kinase inhibitors and implications on obtaining kinase selectivity
Acta Crystallographica Section A Foundations and Advances·2017Open Access
Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model
Bioorganic & Medicinal Chemistry Letters·2017· 36 citedOpen Access
Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors
Bioorganic & Medicinal Chemistry Letters·2017· 5 citedOpen Access
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF–TrkA pathway
Journal of Neuroscience Methods·2017· 3 cited
Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Proceedings of the National Academy of Sciences·2016· 48 citedOpen Access
High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays
SLAS DISCOVERY·2015· 7 citedOpen Access
Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain
Journal of Medicinal Chemistry·2014· 60 citedOpen Access
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Frequent Co-authors

György Buzsáki(18), Germán Barrionuevo(12), Nathaniel N. Urban(9), Kenneth D. Harris(6), Mark O. Urban(5), Xavier Leinekugel(5), Mark T. Bilodeau(5), Christopher S. Burgey(5), Jozsef Csicsvari(4), Hajime Hirase(4), Stefanie A. Kane(4), David A. Lewis(4), Michael Leitl(4), George D. Hartman(4), Rebecca M. Klein(4), Richard L. Kraus(4), Andrea K. Houghton(4), Parul S. Pall(4), Jeanine Ballard(4), Joshua D. Vardigan(4)