Parul S. Pall

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

7h-index133citations10works4.02yr avg
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Research Topics

Pain Mechanisms and Treatments(6), Ion channel regulation and function(6), Neuroscience and Neuropharmacology Research(3), Stress Responses and Cortisol(2), Neuropeptides and Animal Physiology(2)

Publications10 total

Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors
Neurobiology of Pain·2025· 4 citedOpen Access
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Pain·2024· 4 citedOpen Access
Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose
Frontiers in Pharmacology·2021· 7 citedOpen Access
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain
Journal of Medicinal Chemistry·2021· 21 citedOpen Access
Na <sub>v</sub> 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Science Translational Medicine·2021· 20 cited
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate
Pharmaceutical Research·2020· 5 citedOpen Access
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects
Journal of Pain Research·2018· 11 citedOpen Access
Ablation of IB4 non-peptidergic afferents in the rat facet joint prevents injury-induced pain and thalamic hyperexcitability via supraspinal glutamate transporters
Neuroscience Letters·2017· 8 citedOpen Access
Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents
Neuroscience Letters·2015· 27 citedOpen Access
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Journal of Pain·2015· 26 citedOpen Access

Frequent Co-authors

Darrell A. Henze(7), Richard L. Kraus(6), Joshua D. Vardigan(6), Jeanine Ballard(5), Yuxing Li(5), Christopher S. Burgey(5), Andrea K. Houghton(4), Xiaoping Zhou(3), Rebecca M. Klein(3), Michelle K. Clements(3), Marie A. Holahan(3), Jeffrey V. Kras(2), Christine L. Weisshaar(2), Beth A. Winkelstein(2), Fuqiang Zhao(2), M. E. Layton(2), Henry S. Lange(2), Jason M. Uslaner(2), Christopher R. Gibson(2), Dillon S. McDevitt(2)