Marc Therrien

Institute for Research in Immunology and Cancer — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index7.8kcitations75works4.42yr avg
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Research Topics

Melanoma and MAPK Pathways(26), Protein Kinase Regulation and GTPase Signaling(24), Neurobiology and Insect Physiology Research(13), Ubiquitin and proteasome pathways(11), Protein Tyrosine Phosphatases(9)

Publications75 total

BRAF oncogenic mutants evade autoinhibition through a common mechanism
Science·2025· 15 citedOpen Access
Blocking a key node in cancer signalling unlocks therapeutic potential
Nature·2025
RAS signaling gets granular
Nature Chemical Biology·2025
Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration
Developmental Cell·2024· 1 cited
The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction
Nature Structural & Molecular Biology·2024· 6 citedOpen Access
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
iScience·2023Open Access
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
Nature Communications·2023· 8 citedOpen Access
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in <i>Drosophila</i> larvae
2022Open Access
Structural keys unlock RAS–MAPK cellular signalling pathway
Nature·2022· 11 cited
A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene
PLoS Genetics·2021· 5 citedOpen Access
Functional characterization of a PROTAC directed against BRAF mutant V600E
Nature Chemical Biology·2020· 128 citedOpen Access
ERK signalling: a master regulator of cell behaviour, life and fate
Nature Reviews Molecular Cell Biology·2020· 1.1k cited
Rala and the exocyst control Pvr trafficking and signaling to ensure lymph gland homeostasis in <i>Drosophila melanogaster</i>
2020Open Access
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications·2018· 78 citedOpen Access
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect
American Journal of Medical Genetics Part A·2018· 13 cited
MEK drives BRAF activation through allosteric control of KSR proteins
Nature·2018· 151 citedOpen Access
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
Nature Communications·2017· 103 citedOpen Access
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK
Molecular & Cellular Proteomics·2017· 30 citedOpen Access
How Genetics Has Helped Piece Together the MAPK Signaling Pathway
Methods in molecular biology·2016· 14 cited
Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila
Developmental Biology·2016· 18 cited
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Frequent Co-authors

Gerald M. Rubin(13), Hugo Lavoie(12), Frank Sicheri(10), Malha Sahmi(9), David A. Wassarman(8), Jacques Drouin(7), Felix Karim(6), Dariel Ashton‐Beaucage(6), Caroline Baril(6), Henry C. Chang(5), Deborah K. Morrison(5), Thanashan Rajakulendran(4), Noah M. Solomon(4), Neil R. Michaud(4), Neroshan Thevakumaran(4), Ting Jin(4), Christian M. Udell(4), Martin Lefrançois(3), Gino Laberge(3), Mélanie Douziech(3)