Malha Sahmi

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.2kcitations25works10.52yr avg
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Research Topics

Melanoma and MAPK Pathways(8), Protein Kinase Regulation and GTPase Signaling(6), Ubiquitin and proteasome pathways(4), Reproductive Biology and Fertility(3), Reproductive Physiology in Livestock(3)

Publications25 total

BRAF oncogenic mutants evade autoinhibition through a common mechanism
Science·2025· 15 citedOpen Access
The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction
Nature Structural & Molecular Biology·2024· 6 citedOpen Access
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
Nature Communications·2023· 8 citedOpen Access
A putative protein–RNA complex regulates posttranscriptional processing of cytochrome P450 aromatase (CYP19A1) in bovine granulosa cells
Molecular Reproduction and Development·2019· 5 cited
MEK drives BRAF activation through allosteric control of KSR proteins
Nature·2018· 151 citedOpen Access
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
Nature Communications·2017· 103 citedOpen Access
The E3 ligase <i>Kcmf1</i> also rescues <i>Usp47</i> dsRNA and interacts with <i>poe</i>.
Figshare·2016Open Access
<i>Usp47</i> RNAi impacts RTK-RAS signaling downstream of MEK.
Figshare·2016Open Access
Models for regulation of MAPK stability by USP47.
Figshare·2016Open Access
<i>Usp47</i> regulates MAPK levels.
Figshare·2016Open Access
An RNAi screen to identify factors that modify the impact of USP47 on MAPK levels.
Figshare·2016Open Access
<i>Ubc6</i>, <i>poe</i>, and <i>Ufd4</i> dsRNAs alleviate <i>Usp47</i>’s impact on MAPK levels.
Figshare·2016Open Access
USP47 acts post-translationally on MAPK.
Figshare·2016Open Access
The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila
PLoS Biology·2016· 44 citedOpen Access
Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During <i>Drosophila</i> Eye Development Is Promoted by the Small GTPase Rap1
Genetics·2014· 13 citedOpen Access
A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila
PLoS Biology·2014· 65 citedOpen Access
A dimerization-dependent mechanism drives RAF catalytic activation
Nature·2009· 487 cited
The PP2C Alphabet Is a Negative Regulator of Stress-Activated Protein Kinase Signaling in Drosophila
Genetics·2008· 33 citedOpen Access
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling
Proceedings of the National Academy of Sciences·2008· 46 citedOpen Access
Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells <i>in vitro</i>
Reproduction·2006· 59 cited
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Frequent Co-authors

Marc Therrien(19), Dariel Ashton‐Beaucage(10), Samuel Rochette(8), Lemieux Caroline(7), M. Udell Christian(7), Martin Lefrançois(5), Christopher A. Price(5), Frank Sicheri(4), Hugo Lavoie(3), Pierre Maisonneuve(3), Ting Jin(3), Igor Kurinov(3), Caroline Baril(3), Geneviève Arseneault(3), Thanashan Rajakulendran(2), Christian M. Udell(2), Patrick Gendron(2), Edmir Nicola(2), Driss Lajoie(2), Sara A. Marullo(1)