Ibrahim M. Salem

Assiut University — Egypt

Chemistry · Physical Sciences

9h-index209citations28works3.82yr avg
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Research Topics

Synthesis and biological activity(13), Bacterial biofilms and quorum sensing(4), Enzyme function and inhibition(3), Synthesis and Biological Evaluation(3), Synthesis and Characterization of Heterocyclic Compounds(3)

Publications27 total

Integrating synthesis, pharmacological evaluation, and molecular dynamics simulation of novel 8-substituted theophylline hybrids as potential PDE-4B inhibitors, bronchodilators and antibacterial
Bioorganic Chemistry·2026
Disclosing New Insights on Pyrazolo[3,4- <i>d</i> ] Pyrimidine Tethered Diverse Amino Acid Candidates as Potential DHFR Inhibitors and Anti-Virulence Agents
Journal of Microbiology and Biotechnology·2025Open Access
A Comprehensive Review of Pyrazolo[3,4-d] pyrimidine Scaffold Biological Activities
Sphinx journal of Pharmaceutical and Medical Sciences /Sphinx journal of Pharmaceutical and Medical Sciences·2025
Serum S100B As A Potential Biomarker for Cognitive Impairment in Patients with End- Stage Renal Disease.
Zagazig University Medical Journal·2025
Pioneering 1,3,5-triaryl pyrazolines as promising dual inhibitors of COX-2 and 15-LOX endowed with potent anticancer activity: design, synthesis, and in silico study
Bioorganic Chemistry·2025
Synthesis and apoptotic induction of sulfonamide-based chalcone hybrids as first-in-class dual histone deacetylase‑carbonic anhydrase inhibitors with potential anti-tubulin activity
Bioorganic Chemistry·2025· 12 cited
Correlation between Residual Kidney Function, Quality of Life and Cognitive Function in Haemodialysis Patients
Zagazig University Medical Journal·2025
Unveiling ortho-phenolic Mannich ciprofloxacin-chalcone conjugates with potential antineoplastic activity: synthesis, mechanistic study, in silico docking and molecular dynamic simulation
European Journal of Medicinal Chemistry·2025· 1 cited
Exploitation of novel pyrazolo[3,4-d]pyrimidine scaffold tethered to thiazole as potential EGFR/HER2 dual kinase inhibitor to overcome lapatinib resistant breast cancer: Design, synthesis, in silico docking and molecular dynamic simulation
Bioorganic Chemistry·2025· 1 cited
Correction: Hegazy et al. Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Salmonella Typhimurium Pathogenesis. Antibiotics 2022, 11, 465
Antibiotics·2025Open Access
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights
Drug Development Research·2025· 2 cited
Novel chalcone candidates as potential in vitro and in vivo anti-inflammatory agents: Synthesis, in silico docking, multitarget bioevaluation and molecular dynamic simulation
Bioorganic Chemistry·2025· 6 cited
Reprofiling lamivudine as an antibiofilm and anti-pathogenic agent against Pseudomonas aeruginosa
AMB Express·2025· 6 citedOpen Access
Microwave assisted synthesis, biological assessment and in-silico studies of some new 5,5′-(phenylmethylene)bisuracil and dihydropyrido[2,3-d:6,5-d']dipyrimidine derivatives as selective COX-2 inhibitors with potential anti-inflammatory activities
Journal of Molecular Structure·2025· 6 cited
Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies
Bioorganic Chemistry·2025· 12 cited
Triphosgene/KF-mediated acyl fluoride synthesis <i>via in situ</i> fluoro(chloro)phosgene
Organic & Biomolecular Chemistry·2025· 2 cited
Exploitation of Novel Pyrazolo[3,4-D]Pyrimidine Scaffold Tethered to Thiazole as Potential Egfr/Her2 Dual Kinase Inhibitor to Overcome Lapatinib Resistant Breast Cancer: Design, Synthesis, in Silico Docking and Molecular Dynamic Simulation
SSRN Electronic Journal·2025Open Access
Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent in Pseudomonas aeruginosa
Frontiers in Cellular and Infection Microbiology·2024· 20 citedOpen Access
Design, synthesis and antitumor evaluation of novel pyrazolo[3,4- <i>d</i> ]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry·2022· 24 citedOpen Access
Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study
Bioorganic Chemistry·2022· 10 cited
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Frequent Co-authors

Tarek S. Ibrahim(16), Wael A. H. Hegazy(8), Osama I. El‐Sabbagh(7), Samia M. Mostafa(6), Ismail Salama(6), Alaa M. Hayallah(5), Mamdouh F. A. Mohamed(4), El‐Sayed Khafagy(3), Mohammed A. AlAwadh(3), Hadil Faris Alotaibi(2), Doaa Ibrahim(2), Nabil A. Alhakamy(2), Hisham A. Abbas(2), Shaimaa I. Nazeih(2), Rasha M. Allam(2), Deiaa E Elsayed Abouzed(2), Osama A. A. Ahmed(2), Gamal El‐Din A. Abuo‐Rahma(2), Eman A. M. Beshr(2), Tarek Ibrahim(2)