Jonathan Sporn

Medicine · Health Sciences

27h-index3.9kcitations82works2.82yr avg
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Research Topics

Treatment of Major Depression(11), Immunotherapy and Immune Responses(10), Tryptophan and brain disorders(7), T-cell and B-cell Immunology(6), Neuroscience and Neuropharmacology Research(6)

Publications81 total

A novel psychedelic 5-HT <sub>2A</sub> receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer
Journal of Psychopharmacology·2025· 1 cited
Baseline sLAG-3 levels in Caucasian and African-American breast cancer patients
Breast Cancer Research and Treatment·2024
GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents
Neuropsychopharmacology·2024· 10 citedOpen Access
Pharmacokinetic, pharmacodynamic and subjective and effects of the novel 5-HT2A receptor agonist GM-2505 in healthy volunteers
Neuroscience Applied·2024Open Access
22. GM-2505 has Rapid Onset Antidepressant Activity and Causes Dose-Dependent Changes in qEEG With Increasing 5-HT2A Receptor Occupancy
Biological Psychiatry·2023· 1 cited
531. GM-1020 is a Novel, Orally Bioavailable NMDA Antagonist With Improved Separation Between Antidepressant and Ataxic Doses Compared to Ketamine
Biological Psychiatry·2023
527. GM-2040 is a Novel Putative Non-Hallucinogenic 5-HT2A Agonist With Attenuated Head Twitch and Retained Antidepressant Activity
Biological Psychiatry·2023
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
Journal of Neuroinflammation·2023· 13 citedOpen Access
Rapid tolerance to behavioral effects of ethanol in rats: Prevention by R-(−)-ketamine
Pharmacology Biochemistry and Behavior·2021· 6 citedOpen Access
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index
Biological Psychiatry Cognitive Neuroscience and Neuroimaging·2021· 29 citedOpen Access
A phase 1b expansion study of TAS‐102 with oxaliplatin for refractory metastatic colorectal cancer
Cancer·2020· 12 citedOpen Access
R-(−)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder1
Pharmacology Biochemistry and Behavior·2020· 33 cited
Serious adverse events in African–American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare claims cohort
British Journal of Cancer·2019Open Access
A phase I study of TAS-102 in combination with oxaliplatin (TAS-OX) for refractory metastatic colorectal cancer (mCRC).
Journal of Clinical Oncology·2019· 5 cited
immunoassay for TIA would make this a more real- istic goal for application to larger clinical trials.
2017
Diagnostic Accuracy of MRI in Predicting Breast Tumor Size: Comparative Analysis of MRI vs Histopathological Assessed Breast Tumor Size.
PubMed·2015· 21 cited
Pregabalin bei HIV-Infektion
Journal Club Schmerzmedizin·2015
Effects of desvenlafaxine on blood pressure in patients treated for major depressive disorder: a pooled analysis
Current Medical Research and Opinion·2015· 10 cited
Pregabalin for the treatment of postoperative pain: results from three controlled trials using different surgical models
Journal of Pain Research·2014· 46 citedOpen Access
A randomized, double-blind, placebo-controlled trial and open-label extension study to evaluate the efficacy and safety of pregabalin in the treatment of neuropathic pain associated with human immunodeficiency virus neuropathy
Pain·2014· 53 cited
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Frequent Co-authors

Bijay Mukherji(7), Nitya G. Chakraborty(7), M T Ergin(7), H. Necheles(6), Harold Yamase(3), Gary Sachs(3), Ruoyong Yang(3), Scott H. Kurtzman(3), Bernard R. Greenberg(3), Julia Schubert(3), Mattia Veronese(3), Maria Antonietta Nettis(3), Valeria Mondelli(3), Carmine M. Pariante(3), Zoë A. Hughes(3), Harold A. Singer(3), Husseini K. Manji(2), Jorge A. Quiroz(2), Jennifer L. Payne(2), Carlos A. Zarate(2)