John Sinclair

Cancer Research Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index1.9kcitations83works0.52yr avg
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Research Topics

Photosynthetic Processes and Mechanisms(22), Spectroscopy and Quantum Chemical Studies(12), Advanced Proteomics Techniques and Applications(11), Photoreceptor and optogenetics research(10), Light effects on plants(8)

Publications83 total

Expression of Concern: Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Cancer Discovery·2026Open Access
Defining digital twins in a biomanufacturing environment
2025
Transglutaminase 2 function in glioblastoma tumor efferocytosis
Cell Death and Disease·2025· 2 citedOpen Access
Transglutaminase 2 function in glioblastoma tumor efferocytosis
2024Open Access
Intravitreal enzyme replacement preserves retinal structure and function in canine CLN2 neuronal ceroid lipofuscinosis
Experimental Eye Research·2020· 20 citedOpen Access
Neurofilament light is a treatment‐responsive biomarker in CLN2 disease
Annals of Clinical and Translational Neurology·2019· 28 citedOpen Access
Intravitreal Enzyme replacement therapy attenuates retinal disease progression in a canine model of neuronal ceroid lipofuscinosis type 2 (CLN2)
Investigative Ophthalmology & Visual Science·2018Open Access
Intravitreal enzyme replacement therapy attenuates retinal disease progression in a canine model of neuronal ceroid lipofuscinosis type 2 (CLN2)
Molecular Genetics and Metabolism·2018· 2 cited
Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration
Science Signaling·2016· 44 cited
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
Science Signaling·2015· 33 cited
Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies
PROTEOMICS - CLINICAL APPLICATIONS·2014· 53 citedOpen Access
Reproducible Automated Phosphopeptide Enrichment Using Magnetic TiO<sub>2</sub> and Ti-IMAC
Analytical Chemistry·2014· 91 citedOpen Access
Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome
Nature Methods·2014· 62 citedOpen Access
62: Proffered Paper: Cell-specific proteomic analysis of contact-initiated tumour-endothelial signalling identifies novel regulators of transendothelial migration
European Journal of Cancer·2014
Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics
Journal of Proteome Research·2014· 37 cited
Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling
BMC Clinical Pathology·2014· 25 citedOpen Access
PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium
Journal of Cell Science·2014· 32 cited
Abstract 3404: Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Cancer Research·2013· 1 cited
Proteomic Profiling of Ovarian Cancer Models Using TMT-LC-MS/MS
Methods in molecular biology·2013· 6 cited
Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma
Cancer Discovery·2012· 372 citedOpen Access
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Frequent Co-authors

John F. Timms(12), Claus Jørgensen(7), T. J. Arnason(5), Alison E.M. Vickers(4), Jonathan D. Worboys(3), Mark C. Willingham(3), Stéphane Camuzeaux(3), Robyn L. Fisher(3), Kelly McMahon(2), Fausto Andreola(2), Michael H. Chapman(2), Ross C. Smith(2), Stephen P. Pereira(2), Amna Butt(2), Jessica L. Worthington(2), Nic Jones(2), Michael D. Waterfield(2), Yinyin Yuan(2), Aleksandra Gentry‐Maharaj(2), Usha Menon(2)