Gloria López‐Castejón

Manchester Academic Health Science Centre — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index6.6kcitations85works2.82yr avg
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Research Topics

Inflammasome and immune disorders(43), Heme Oxygenase-1 and Carbon Monoxide(13), Immune Response and Inflammation(11), CRISPR and Genetic Engineering(11), interferon and immune responses(11)

Publications85 total

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α
2025Open Access
Deletion of <i>CH25H</i> and <i>LIPA</i> Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant <sup>‡</sup>
2025· 1 citedOpen Access
Keratinocyte arginase 1 regulates proinflammatory responses and drives re-epithelialization via lipocalin 2
British Journal of Dermatology·2025Open Access
Lysosome positioning affects NLRP3 inflammasome activation
2025· 1 citedOpen Access
Very Early-Onset IBD-Associated IL-18opathy Treated with an Anti-IL-18 Antibody
Journal of Clinical Medicine·2024· 3 citedOpen Access
Pyroptosis leads to loss of centrosomal integrity in macrophages
Cell Death Discovery·2024· 2 citedOpen Access
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
Nature Communications·2024· 6 citedOpen Access
Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages
Life Science Alliance·2024· 9 citedOpen Access
Pyroptosis leads to loss of centrosomal integrity in macrophages
2023· 1 citedOpen Access
Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function
2023Open Access
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Science Signaling·2023· 47 citedOpen Access
Inflammation in LAL deficiency is driven by substrate accumulation
Molecular Genetics and Metabolism·2023
Method to Measure Ubiquitination of NLRs
Methods in molecular biology·2023
NLRP3 inflammasome triggers interleukin‐37 release from human monocytes
European Journal of Immunology·2022· 9 citedOpen Access
Editorial: Neurological, Metabolic and Inflammatory Disorders: A Common Root in Inflammasome
Frontiers in Pharmacology·2021Open Access
Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages
Frontiers in Immunology·2021· 27 citedOpen Access
NLRP3 activation in response to disrupted endocytic traffic
2021· 8 citedOpen Access
Corrigendum: Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro
Frontiers in Immunology·2021· 3 citedOpen Access
NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet‐induced obesity
British Journal of Pharmacology·2021· 19 citedOpen Access
Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”
Genome biology·2021· 8 citedOpen Access
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Frequent Co-authors

David Brough(26), Pablo Pelegrı́n(9), Víctoriano Mulero(8), Carolina Pellegrini(7), Jack Green(6), Fatima Martín‐Sánchez(6), Pablo Palazón‐Riquelme(6), José Meseguer(6), Luca Antonioli(5), Corrado Blandizzi(5), Matteo Fornai(5), Nadia Luheshi(5), Yu Shi(4), Catherine B. Lawrence(4), María P. Sepulcre(4), Vincent Compan(3), Alberto Baroja‐Mazo(3), Diego Angosto-Bazarra(3), Annmarie Surprenant(3), Ádám Dénes(3)