Paul B. Sigler

Biochemistry, Genetics and Molecular Biology · Life Sciences

74h-index29.9kcitations205works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(46), Protein Structure and Dynamics(31), Enzyme Structure and Function(31), DNA and Nucleic Acid Chemistry(30), Bacterial Genetics and Biotechnology(20)

Publications205 total

Correction: Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure
PLoS Biology·2010Open Access
Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure
PLoS Biology·2009· 125 citedOpen Access
The complete structure of the archaeal 13-subunit DNA-directed RNA Polymerase
2009
Molecular architecture of Gα <sub>o</sub> and the structural basis for RGS16-mediated deactivation
Proceedings of the National Academy of Sciences·2008· 66 citedOpen Access
E. coli TRP holorepressor, orthorhombic crystal form
2007
The Structure of ClpB
Cell·2003· 429 citedOpen Access
Crystal structure of groEL-groES
2003· 1 cited
Crystal structure of a transcription factor IIIB core interface ternary complex
Nature·2003· 83 cited
ROLE OF THE GAMMA-PHOSPHATE OF ATP IN TRIGGERING PROTEIN FOLDING BY GROEL-GROES: FUNCTION, STRUCTURE AND ENERGETICS
Chemistry of Materials·2003· 1 cited
Crystal structure of a yeast Brf1-TBP-DNA ternary complex
2002
The X-ray Crystal Structure of the NF-κB p50·p65 Heterodimer Bound to the Interferon β-κB Site
Journal of Biological Chemistry·2002· 113 citedOpen Access
Crystal Structure of β-Arrestin at 1.9 Å
Structure·2001· 394 citedOpen Access
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å
Nature·2001· 261 cited
[19] Preparation of components of archaeal transcription preinitiation complex
Methods in enzymology on CD-ROM/Methods in enzymology·2001· 9 cited
The Sir Hans Krebs Lecture awarded posthumously to Paul Sigler: This FEBS sponsored lecture will be a presentation by Professor Thomas Steitz on the research and work of the late Professor Paul Sigler. The presentation will focus on his work on G-proteins
Biochemical Society Transactions·2000
CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
2000
RGS9 RGS DOMAIN
2000
A dynamic model for the allosteric mechanism of GroEL 1 1Edited by A. Fersht
Journal of Molecular Biology·2000· 239 cited
Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy
Science·2000· 686 cited
Cell science and protein crystal growth research for the International Space Station
Journal of Cellular Biochemistry·2000· 3 cited
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Frequent Co-authors

Zbyszek Otwinowski(9), A. Joachimiak(5), Heidi E. Hamm(5), Arthur L. Horwich(4), David G. Lambright(4), Richard W. Schevitz(4), David L. Scott(4), Michael H. Gelb(4), Ben F. Luisi(3), John Sondek(3), Andrew Bohm(3), Catherine L. Lawson(3), Joseph P. Noel(3), Steven P. White(3), Zhaohui Xu(3), Carsten J. Schubert(3), Vsevolod V. Gurevich(3), Leonard P. Freedman(2), Keith R. Yamamoto(2), Rashmi S. Hegde(2)