David G. Lambright

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

52h-index10.1kcitations166works2.32yr avg
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Research Topics

Cellular transport and secretion(71), Retinal Development and Disorders(20), Calcium signaling and nucleotide metabolism(19), Protein Kinase Regulation and GTPase Signaling(17), Microtubule and mitosis dynamics(17)

Publications165 total

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling
2026Open Access
Heterozygous <i>RAB3A</i> variants cause cerebellar ataxia by a partial loss-of-function mechanism
Brain·2025· 4 cited
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling
2024· 3 citedOpen Access
Systems-level effects of allosteric perturbations to a model molecular switch
Nature·2021· 24 citedOpen Access
Propelling COPII vesicle biogenesis at the endoplasmic reticulum
Structure·2021· 1 citedOpen Access
High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins
Methods in molecular biology·2021· 2 cited
Decision letter: Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
2020Open Access
Coordination of Grp1 recruitment mechanisms by its phosphorylation
Molecular Biology of the Cell·2020· 3 citedOpen Access
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson’s Disease
Structure·2020Open Access
Biophysical basis of cellular multi-specificity encoded in a model molecular switch
2020Open Access
Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes
Structure·2019· 17 citedOpen Access
Decision letter: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
2019Open Access
Decision letter: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
2019Open Access
TRAPPing a Rab GTPase by the Tail
Developmental Cell·2019Open Access
Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors
Structure·2017· 14 citedOpen Access
Model for extended volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A Arf6 Q67L fusion protein
2017
Model for compact volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A 6GS Arf6 Q67L fusion protein
2017
Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses
Current Biology·2016· 5 citedOpen Access
Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC)
Small GTPases·2016Open Access
Invited review: Small GTPases and their GAPs
Biopolymers·2016· 71 citedOpen Access
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Frequent Co-authors

Silvia Corvera(8), Steven G. Boxer(7), Anna Delprato(6), Deirdre C. Lawe(6), Ashwini Kumar Mishra(6), Heidi E. Hamm(5), Paul B. Sigler(5), Sudharshan Eathiraj(5), Kevin E. Fogarty(5), John Sondek(4), Craig R. Roy(4), John J. Dumas(4), Eric Merithew(4), Jonathan P. DiNitto(4), Andrew Bohm(3), Xiaojing Pan(3), Michael Czech(3), Susan Hayes(3), Thomas C. Cronin(3), Lawrence M. Lifshitz(3)