John J. Dumas

Women's Health Research Institute — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index1.1kcitations16works0.02yr avg
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Research Topics

Cellular transport and secretion(5), Lipid Membrane Structure and Behavior(3), Platelet Disorders and Treatments(3), Neuropeptides and Animal Physiology(3), Receptor Mechanisms and Signaling(3)

Publications16 total

Crystal Structure of the Wild-type von Willebrand Factor A1-Glycoprotein Ibα Complex Reveals Conformation Differences with a Complex Bearing von Willebrand Disease Mutations
Journal of Biological Chemistry·2004· 199 citedOpen Access
Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution
2004
Crystal Structure of the GpIbα-Thrombin Complex Essential for Platelet Aggregation
Science·2003· 154 cited
Sequential Roles for Phosphatidylinositol 3-Phosphate and Rab5 in Tethering and Fusion of Early Endosomes via Their Interaction with EEA1
Journal of Biological Chemistry·2002· 156 citedOpen Access
Research Article The 2.4-Å crystal structure of the penicillin-resistant penicil- lin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin
2002
Multivalent Endosome Targeting by Homodimeric EEA1
Molecular Cell·2001· 251 citedOpen Access
EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate
2001
Structural Plasticity of an Invariant Hydrophobic Triad in the Switch Regions of Rab GTPases Is a Determinant of Effector Recognition
Journal of Biological Chemistry·2001· 107 citedOpen Access
A Helical Turn Motif in Mss4 Is a Critical Determinant of Rab Binding and Nucleotide Release
Biochemistry·2001· 27 cited
CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS
2001
Structural basis of activation and GTP hydrolysis in Rab proteins
Structure·1999· 125 citedOpen Access
GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION
1998
Gsα meets its target – shedding light on a key signal transduction event
Structure·1998· 7 citedOpen Access
The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond.
Proceedings of the National Academy of Sciences·1996· 62 cited
Chemical Cross-Linking of the Substance P (NK-1) Receptor to the α Subunits of the G Proteins G<sub>q</sub> and G<sub>11</sub>
Biochemistry·1996· 48 cited
Localization of the Peptide Binding Domain of the NK‐1 Tachykinin Receptor Using Photoreactive Analogues of Substance P
Annals of the New York Academy of Sciences·1995· 5 cited

Frequent Co-authors

David G. Lambright(9), Eric Merithew(4), Deirdre C. Lawe(4), Silvia Corvera(3), W.S. Somers(3), Lidia Mosyak(3), Norman D. Boyd(3), Deepa Rajamani(2), R. Anand Kumar(2), Thomas McDonagh(2), Francis Sullivan(2), Mark Stahl(2), Zhongyuan Zhu(2), R. Kage(2), James E. Krause(2), Susan E. Leeman(2), S. E. Lietzke(2), E. Sudharshan(1), Susan Hayes(1), Anil Chawla(1)