Steven Dabbs

GlaxoSmithKline (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index987citations28works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(7), Synthesis and Biological Evaluation(6), Chemical Synthesis and Analysis(5), Cancer therapeutics and mechanisms(5), Phenothiazines and Benzothiazines Synthesis and Activities(5)

Publications28 total

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases
Bioorganic & Medicinal Chemistry Letters·2016· 46 citedOpen Access
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
Bioorganic & Medicinal Chemistry Letters·2013· 63 citedOpen Access
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
Bioorganic & Medicinal Chemistry Letters·2011· 46 citedOpen Access
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases
Bioorganic & Medicinal Chemistry Letters·2011· 49 citedOpen Access
ChemInform Abstract: The Design of Efficient and Selective Routes to Pyridyl Analogues of 3‐Oxo‐3,4‐dihydro‐2H‐1,4‐(benzothiazine or benzoxazine)‐6‐carbaldehydes.
ChemInform·2010
ChemInform Abstract: The Design of Efficient and Selective Routes to Pyridyl Analogues of 2,3‐Dihydro‐1,4‐benzodioxin‐6‐carbaldehyde.
ChemInform·2010
The design of efficient and selective routes to pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes
Tetrahedron Letters·2010· 17 cited
The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde
Tetrahedron Letters·2010· 14 cited
Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides
Tetrahedron Letters·2010· 22 cited
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents
Bioorganic & Medicinal Chemistry Letters·2000· 22 citedOpen Access
Biarylcarbamoylindolines Are Novel and Selective 5-HT<sub>2C</sub> Receptor Inverse Agonists:  Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent
Journal of Medicinal Chemistry·2000· 79 citedOpen Access
A Novel, Potent, and Selective 5-HT<sub>7</sub>Antagonist:  (<i>R</i>)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Journal of Medicinal Chemistry·2000· 248 citedOpen Access
Model studies on a synthetically facile series of N-substituted phenyl-N′-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists
Bioorganic & Medicinal Chemistry·1999· 8 cited
Novel and Selective 5-HT<sub>2C/2B</sub> Receptor Antagonists as Potential Anxiolytic Agents:  Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines
Journal of Medicinal Chemistry·1998· 64 citedOpen Access
(<i>R</i>)-3,<i>N</i>-Dimethyl-<i>N</i>-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide:  The First Selective 5-HT<sub>7</sub>Receptor Antagonist
Journal of Medicinal Chemistry·1998· 102 citedOpen Access
Design of [<i>R</i>-(<i>Z</i>)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the <i>N</i>-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Journal of Medicinal Chemistry·1997· 30 citedOpen Access
ChemInform Abstract: Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5‐HT2C/2B Receptor Antagonists.
ChemInform·1997· 1 cited
Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT<sub>2C/2B</sub> Receptor Antagonists
Journal of Medicinal Chemistry·1996· 31 citedOpen Access
ChemInform Abstract: Pseudohalogen Chemistry. Part 11. Some Aspects of the Chemistry of . alpha.‐Thiocyanato‐β‐dicarbonyl Compounds.
ChemInform·1994
ChemInform Abstract: 1,2,5,6‐Tetrahydropyridine Oxime Ethers Incorporating Electron Withdrawing Groups are Potent and Selective Muscarinic Agonists.
ChemInform·1994
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Frequent Co-authors

Graham J. Riley(12), David T. Davies(12), Graham E. Jones(12), Steven M. Bromidge(11), Timothy J. Miles(9), Alan J. Hennessy(9), Neil D. Pearson(9), D. Malcolm Duckworth(8), Ian T. Forbes(8), Frank D. King(8), Damian V. Saunders(7), Gerald Brooks(7), Roger E. Markwell(7), Thomas P. Blackburn(6), G.A. Kennett(6), Martyn Wood(6), Frank Brown(6), Frederick Cassidy(6), Michael Clark(6), Julia M. Loudon(6)