Steven M. Bromidge

Evotec (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index3.1kcitations70works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(21), Synthesis and Biological Evaluation(17), Neurotransmitter Receptor Influence on Behavior(14), Phenothiazines and Benzothiazines Synthesis and Activities(13), Pharmacological Receptor Mechanisms and Effects(12)

Publications70 total

FC080: A Systems Nephrology Framework for the Molecular Classification of Chronic Kidney Disease
Nephrology Dialysis Transplantation·2022
FC080: A Systems Nephrology Framework for the Molecular Classification of Chronic Kidney Disease
Nephrology Dialysis Transplantation·2022
Guiding Medicinal Chemistry with Fragment Molecular Orbital (FMO) Method
Methods in molecular biology·2020· 14 cited
Design, synthesis and structure–activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)
Bioorganic & Medicinal Chemistry Letters·2014· 9 citedOpen Access
Inside Cover: Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex (ChemMedChem 4/2014)
ChemMedChem·2014· 3 cited
Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex
ChemMedChem·2014· 168 cited
Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)
Bioorganic & Medicinal Chemistry Letters·2013· 14 citedOpen Access
Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione
2013
Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid
2013· 1 cited
Identification of novel NK1/NK3 dual antagonists for the potential treatment of schizophrenia
Bioorganic & Medicinal Chemistry Letters·2011· 11 citedOpen Access
Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT<sub>1A/B/D</sub> Receptor Antagonist
Journal of Medicinal Chemistry·2010· 12 citedOpen Access
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT<sub>1A/B/D</sub> Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4<i>H</i>-imidazo[5,1-<i>c</i>][1,4]benzoxazine-3-carboxamide (GSK588045)
Journal of Medicinal Chemistry·2010· 35 citedOpen Access
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors—Part II
Bioorganic & Medicinal Chemistry Letters·2009· 20 cited
ChemInform Abstract: Synthesis of 7‐Substituted‐(2,3‐dihydro‐1,4‐benzodioxin‐5‐yl)‐piperazine.
ChemInform·2008
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 30 citedOpen Access
Synthesis of 7-Substituted-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine
Synthetic Communications·2008· 4 cited
SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models
European Journal of Pharmacology·2006· 228 cited
Discovery of a Potent and Selective 5‐ht<sub>5A</sub> Receptor Antagonist (I) by High‐Throughput Chemistry.
ChemInform·2005
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2005· 22 citedOpen Access
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Frequent Co-authors

Graham J. Riley(26), Derek N. Middlemiss(11), Frank D. King(11), G.A. Kennett(9), Martyn Wood(9), Vicky Holland(9), Ian T. Forbes(9), Steven Dabbs(9), Brenda Trail(8), David R. Thomas(8), Stephen F. Moss(8), Barry S. Orlek(8), Tania O. Stean(7), Thomas P. Blackburn(7), Gary Price(6), Peter J. Lovell(6), D. Malcolm Duckworth(6), Stephen E. Clarke(6), Carol Routledge(6), Michael Clark(6)