Barry S. Orlek

University of Leeds — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.1kcitations63works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(19), Synthesis and Biological Evaluation(14), Receptor Mechanisms and Signaling(11), Asymmetric Synthesis and Catalysis(8), Click Chemistry and Applications(7)

Publications63 total

ChemInform Abstract: Synthesis of α‐Silylalkylbenzoxazoles and Oxazoles from Stable Silylketenes.
ChemInform·2009
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor
Bioorganic & Medicinal Chemistry Letters·2009· 6 citedOpen Access
Synthesis of α-silylalkylbenzoxazoles and oxazoles from stable silylketenes
Tetrahedron·2009· 6 cited
A Practical Synthesis of Differentially Protected 4,4′-Dipiperidinyl Ethers: Novel Ligands of Pharmaceutical Interest
Synlett·2009· 4 cited
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
Biochemical Pharmacology·2007· 64 cited
Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors
European Journal of Medicinal Chemistry·2003· 52 cited
<i>N</i>-Benzyl-<i>N</i>-(methoxymethyl)-<i>N</i>-trimethylsilylmethylamine
Encyclopedia of Reagents for Organic Synthesis·2001· 2 cited
Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides
Bioorganic & Medicinal Chemistry·2000· 10 cited
Characterisation of SB-221420-A — a neuronal Ca2+ and Na+ channel antagonist in experimental models of stroke
European Journal of Pharmacology·2000· 13 cited
ChemInform Abstract: A Stereoselective Synthesis of 3‐Substituted Hexahydroindeno[2,1‐b]pyrroles via an Intramolecular Azomethine Ylide Cycloaddition.
ChemInform·1999
ChemInform Abstract: Identification of a Series of 1,2,3,4‐Tetrahydroisoquinolinyl Benzamides with Potential Anticonvulsant Activity.
ChemInform·1999
A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition
Tetrahedron·1998· 14 cited
Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity
Bioorganic & Medicinal Chemistry Letters·1998· 16 cited
ChemInform Abstract: Stereoselective Construction of Vicinal Diamines. Part 3. Routes to the Benz[f]indeno[1,7‐bc]azepine and Benz[e]indeno[2,1‐b][1,4]diazepine Ring Systems.
ChemInform·1998
A molecular mechanism for toxin block in N-type calcium channels
Protein Engineering Design and Selection·1998· 17 cited
Design of [<i>R</i>-(<i>Z</i>)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the <i>N</i>-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Journal of Medicinal Chemistry·1997· 30 citedOpen Access
SB 202026: A Novel Muscarinic Partial Agonist with Functional Selectivity for M1 Receptors
Journal of Pharmacology and Experimental Therapeutics·1997· 47 cited
Stereoselective construction of vicinal diamines. Part 3.1 Routes to the benz[ f ]indeno[1,7-bc] azepine and benz[e]indeno[2,1-b][1,4]diazepine ring systems
Journal of the Chemical Society Perkin Transactions 1·1997· 2 cited
ChemInform Abstract: A Stereoselective Route to trans‐1‐Arylthio‐2‐aminoindans.
ChemInform·1996
A Stereoselective Route to trans-1-Arylthio-2-aminoindanes
Synlett·1996· 3 cited
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Frequent Co-authors

Peter G. Sammes(13), Graham J. Riley(12), Michael Clark(9), Steven M. Bromidge(9), Michael S. Hadley(8), Frederick Cassidy(8), David J. Weller(8), Frank Brown(7), Julie A. Hawkins(6), Paul Wyman(5), V Knott-Hunziker(5), Julia M. Loudon(5), Geoffrey Stemp(5), Steven Dabbs(4), John D. Harling(4), Richard E. Faulkner(4), Harry J. Wadsworth(3), Stephen G. Waley(3), Gordon Bruton(3), Tania O. Stean(3)