Sharon Mavroukakis

Center for Biologics Evaluation and Research — United States

Medicine · Health Sciences

31h-index16.4kcitations86works11.02yr avg
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Research Topics

CAR-T cell therapy research(35), Immunotherapy and Immune Responses(27), Glycosylation and Glycoproteins Research(15), Monoclonal and Polyclonal Antibodies Research(15), Cancer Immunotherapy and Biomarkers(11)

Publications86 total

CD22-directed CAR-T cells induce complete remissions in high-risk follicular and Mantle Cell Lymphoma with limited neurotoxicity
Blood·2025Open Access
Sequential CD19 and CD22 CART for relapsed and refractory B cell ALL: Phase I results
Blood·2025Open Access
949  <i>In vitro</i> and <i>in vivo</i> efficacy of the antibody-drug-conjugate (ADC) PB-vcMMAE-5 against human carcinoma expressing truncated core 2 O-glycans
Regular and Young Investigator Award Abstracts·2025Open Access
269 Humanized anti-CAR antibodies affect durable response to GD2-CAR T-cells in diffuse midline glioma
Regular and Young Investigator Award Abstracts·2025Open Access
CTIM-05. HUMANIZED ANTI-CAR ANTIBODIES AFFECT DURABLE RESPONSE TO GD2-CAR T-CELLS IN DIFFUSE MIDLINE GLIOMA
Neuro-Oncology·2025Open Access
Abstract B068: <i>In vitro</i> and <i>in vivo</i> efficacy of the antibody-drug-conjugate (ADC) PB-vcMMAE-5 against human ovarian cancer expressing truncated core 2 O-glycans
Cancer Research·2025
Abstract 4783: Development and characterization of an antibody-drug conjugate (ADC) utilizing PB-223, a novel monoclonal antibody (mAb) specifically targeting core 2 O-glycans on human carcinomas
Cancer Research·2025
Abstract A009: Development of monoclonal antibodies targeting truncated O-glycans expressed specifically by cancer cells offers a novel strategy to enhance cancer immunotherapy efficacy
Cancer Immunology Research·2025
CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma with Superior Safety and Absence of Neurotoxicity
Transplantation and Cellular Therapy·2025· 1 cited
Author Correction: Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Nature·2024· 12 citedOpen Access
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Nature·2024· 126 citedOpen Access
CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma
Blood·2024· 2 citedOpen Access
Role of B Cell Recovery in Relapse Risk and CD19 Phenotype Following Real-World Use of Tisagenlecleucel for Pediatric B-Acute Lymphoblastic Leukemia: A Multi-Institutional Retrospective Study
Blood·2024· 3 cited
CD22-Directed CAR T-Cell Therapy for Large B-Cell Lymphomas Progressing after CD19-Directed CAR T-Cell Therapy: Continued Durable Remissions at 3-Year Follow-up
Blood·2024
IMMU-60. MYELOID POPULATIONS MODULATE GD2 CAR T CELL ACTIVITY IN DIFFUSE MIDLINE GLIOMA
Neuro-Oncology·2024· 1 citedOpen Access
1101 Affinity maturation and characterization of a novel O-glycan epitope targeting anti-human carcinoma monoclonal antibody (mAb) PB-223
Regular and Young Investigator Award Abstracts·2024Open Access
A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia
Blood·2024· 21 citedOpen Access
CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study
The Lancet·2024· 46 citedOpen Access
Sequential intravenous and intracerebroventricular GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas
2024· 6 citedOpen Access
DIPG-47. SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS
Neuro-Oncology·2024Open Access
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Frequent Co-authors

Steven A. Rosenberg(22), Liora M. Schultz(19), Emily Egeler(19), Suzanne L. Topalian(17), Richard M. Sherry(17), Christina Baggott(17), Bita Sahaf(16), Kara L. Davis(14), Steven A. Feldman(14), Sneha Ramakrishna(13), Michael Kunicki(13), Nicholas P. Restifo(12), Donald E. White(12), Crystal L. Mackall(12), Kathleen E. Morton(11), Robbie G. Majzner(11), Shabnum Patel(11), Jennifer Moon(11), Courtney Erickson(11), Snehit Prabhu(11)