Junichi Shioi

James J. Peters VA Medical Center — United States

Medicine · Health Sciences

34h-index3.9kcitations67works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(29), Wnt/β-catenin signaling in development and cancer(10), Neuroscience and Neuropharmacology Research(9), Cellular transport and secretion(9), Photoreceptor and optogenetics research(9)

Publications67 total

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection<i>via</i>γ-secretase-independent transcriptional mechanisms
The FASEB Journal·2015· 21 citedOpen Access
Presenilin-1/γ-Secretase Controls Glutamate Release, Tyrosine Phosphorylation, and Surface Expression of N-Methyl-d-aspartate Receptor (NMDAR) Subunit GluN2B
Journal of Biological Chemistry·2013· 4 citedOpen Access
P3–038: A novel PKC‐dependent phosphorylation of doublecortin: Potential implications in the context of excitotoxicity
Alzheimer s & Dementia·2013Open Access
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors
Neurobiology of Aging·2012· 40 cited
Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling
Neurobiology of Aging·2011· 104 cited
Inhibitors of γ‐secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
The FASEB Journal·2011· 34 cited
P2‐302: Progranulin activates MAP kinase and protects neurons against glutamate toxicity and oxidative stress
Alzheimer s & Dementia·2010
p120 Catenin Recruits Cadherins to γ-Secretase and Inhibits Production of Aβ Peptide
Journal of Biological Chemistry·2008· 29 citedOpen Access
P4‐195: Presenilin1 prevents neurodegeneration by stimulating PI3K/Akt neuroprotective signaling: Effects of PS1 familial Alzheimer's disease mutations
Alzheimer s & Dementia·2008
P4‐216: The cadherin‐binding factor p120 promotes the γ‐secretase processing of cadherins but inhibits APP processing and Aβ production
Alzheimer s & Dementia·2008
Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling
Journal of Neuroscience·2008· 62 citedOpen Access
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor
Journal of Biological Chemistry·2007· 118 citedOpen Access
FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ
Journal of Neurochemistry·2006· 77 cited
P3–220: Test of PI3K/Akt signaling hypothesis for mechanism of AD using unique PS1 FAD mutations that do not affect Aβ42 production
Alzheimer s & Dementia·2006Open Access
The cytoplasmic sequence of E‐cadherin promotes non‐amyloidogenic degradation of Aβ precursors
Journal of Neurochemistry·2006· 19 citedOpen Access
Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability
Journal of Biological Chemistry·2005· 69 citedOpen Access
P4-307 PS1 suppresses apoptosis and prevents Tau hyperphosphorylation via cadherin/PI3K signaling; effects of PS1 FAD mutations
Neurobiology of Aging·2004
O3-05-02 FAD-linked presenilin-1 mutations affect the N-cadherin/CBP signaling pathway via a loss-of-function mechanism
Neurobiology of Aging·2004
P4-320 Role of presenilin 1 and its FAD mutations in cadherin/PI3K/AKT pathway investigated in animal models
Neurobiology of Aging·2004
PS1 activates PI3K thus inhibiting GSK‐3 activity and tau overphosphorylation: effects of FAD mutations
The EMBO Journal·2004· 287 citedOpen Access
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Frequent Co-authors

Nikolaos K. Robakis(33), Anastasios Georgakopoulos(12), Spiros Efthimiopoulos(10), Zhiping Shao(7), Victor L. Friedrich(7), Philippe Marambaud(5), Paul H. Wen(5), Lia Baki(5), Y Imae(5), Barry Taylor(5), Menelas N. Pangalos(5), Julien Bruban(4), Nikolaos Tezapsidis(4), Anfan Wu(4), Gaël Barthet(4), Rachael L. Neve(3), Shusuke Matsuura(3), Kumar Sambamurti(3), Claudia Litterst(3), Gregory A. Elder(3)