Nikolaos K. Robakis

Icahn School of Medicine at Mount Sinai — United States

Medicine · Health Sciences

56h-index9.3kcitations190works11.72yr avg
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Research Topics

Alzheimer's disease research and treatments(97), Cholinesterase and Neurodegenerative Diseases(26), Prion Diseases and Protein Misfolding(24), Wnt/β-catenin signaling in development and cancer(15), Computational Drug Discovery Methods(14)

Publications185 total

Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease
Brain·2025· 1 cited
PS1 regulates processing and angiogenic signalling of VEGFR2; effects of FAD mutants
Alzheimer s & Dementia·2024Open Access
Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit
Ageing Research Reviews·2024· 34 cited
Revision of Alzheimer’s diagnostic criteria or relocation of the Potemkin village
Ageing Research Reviews·2023· 8 citedOpen Access
FAD mutants decrease brain neovascularization and neuronal survival by targeting angiogenic mechanisms of PS1/γ‐secretase
Alzheimer s & Dementia·2023Open Access
Passive Alzheimer’s immunotherapy: A promising or uncertain option?
Ageing Research Reviews·2023· 46 cited
The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes
Journal of Alzheimer s Disease·2023· 46 citedOpen Access
The amyloid cascade hypothesis: an updated critical review
Brain·2023· 241 citedOpen Access
The anti-amyloid monoclonal antibody Lecanemab: 16 cautionary notes
Zenodo (CERN European Organization for Nuclear Research)·2023· 6 citedOpen Access
Presenilin1 FAD mutants and γ‐secretase inhibitors decrease VEGFR2 signaling and block angiogenic functions of brain endothelial cells
Alzheimer s & Dementia·2022
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling
Nature Cell Biology·2022· 22 citedOpen Access
Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and function
2021Open Access
On the Nomenclature of the Alzheimer’s Disease Amyloid and Its Precursor1
Journal of Alzheimer s Disease·2021Open Access
Detection of brain neovascularization induced by focal ischemia
Molecular Psychiatry·2021
PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival
Molecular Psychiatry·2020· 8 citedOpen Access
Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-aspartate receptor
Brain Communications·2020· 9 citedOpen Access
What Do Recent Clinical Trials Teach Us About the Etiology of AD
Advances in experimental medicine and biology·2020· 7 cited
Substrate interaction inhibits γ-secretase production of amyloid-β peptides
Chemical Communications·2020· 4 citedOpen Access
P4‐687: SUBSTRATE BINDING INHIBITS γ‐SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN
Alzheimer s & Dementia·2019
Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci
Human Molecular Genetics·2018· 7 citedOpen Access
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Frequent Co-authors

Junichi Shioi(14), Anastasios Georgakopoulos(10), Lia Baki(7), Paul H. Wen(5), Vahram Haroutunian(5), Philippe Marambaud(4), Zhiping Shao(4), Victor L. Friedrich(4), John P. Anderson(4), Patrick R. Hof(4), Gregory A. Elder(4), Claudia Litterst(4), Gloria Wolfe(3), Miguel A. Pappolla(3), Panos Roussos(3), Georgios Voloudakis(3), Spiros Efthimiopoulos(3), Pankaj Mehta(3), Kumar Sambamurti(3), Constantin Bouras(3)