John Jacob

University of Oxford — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index844citations23works9.72yr avg
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Research Topics

Hedgehog Signaling Pathway Studies(9), Developmental Biology and Gene Regulation(6), Pluripotent Stem Cells Research(6), Epigenetics and DNA Methylation(5), Glioma Diagnosis and Treatment(4)

Publications23 total

Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states
Neuro-Oncology Advances·2024· 4 citedOpen Access
Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards <i>in vivo</i> malignant cell states
2024· 1 citedOpen Access
<i>PTCH1</i> -mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis
Disease Models & Mechanisms·2024· 24 citedOpen Access
NON-CELL AUTONOMOUS INDUCTION OF A CANCER STEM CELL MOLECULAR PHENOTYPE IN AN IN VITRO MODEL OF SONIC HEDGEHOG MEDULLOBLASTOMA
Neuro-Oncology·2023Open Access
<i>PTCH1</i> mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis
2023Open Access
Modelling SHH-Medulloblastoma Using Cerebellar Organoids
Neuro-Oncology·2022Open Access
Messenger RNA brings gene editing a step closer to treat muscular dystrophies
Molecular Therapy — Nucleic Acids·2022· 1 citedOpen Access
Cerebellar Modelling Using Human Induced Pluripotent Stem Cells
Neuromethods·2022· 5 cited
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells
The CRISPR Journal·2021· 5 cited
Deconstructing cerebellar development cell by cell
PLoS Genetics·2020· 63 citedOpen Access
Lipid metabolism fattens up hedgehog signaling
BMC Biology·2017· 62 citedOpen Access
Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders
Epilepsia·2015· 63 citedOpen Access
Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome
Human Molecular Genetics·2015· 97 citedOpen Access
A CHEMICAL–GENETICS APPROACH TO STUDY THE MOLECULAR PATHOLOGY OF CENTRAL SEROTONIN ABNORMALITIES IN FETAL VALPROATE SYNDROME
Journal of Neurology Neurosurgery & Psychiatry·2013· 2 cited
Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1
Current Biology·2013· 31 citedOpen Access
[P1.23]: Repression of the proneural factor Ascl1 by retinoid signalling restricts neuronal fate choices in the ventral spinal cord
International Journal of Developmental Neuroscience·2010
S11-03 Serotonergic neurogenesis from a bipotent progenitor pool serves as a model for the coordination of neuronal birth order and identity by intrinsic genetic programs
Mechanisms of Development·2009
Temporal control of neuronal diversity: common regulatory principles in insects and vertebrates?
Development·2008· 98 cited
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis
Nature Neuroscience·2007· 89 cited
Gli proteins and the control of spinal‐cord patterning
EMBO Reports·2003· 226 citedOpen Access
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Frequent Co-authors

Esther B. E. Becker(8), James Briscoe(7), Max J. van Essen(6), Sally A. Cowley(4), Christopher I. Milton(3), Joey Riepsaame(3), Max van Essen(3), Benjamin Schuster‐Böckler(3), Robert Blassberg(2), Patrick Pla(2), Sam Nayler(2), Sarah Guthrie(2), Steven Moore(2), Rosa Gonzalez‐Quevedo(2), Javier Terriente(2), Elizabeth J. Apsley(2), Alina Nicheperovich(2), Cédric Maurange(1), Alex P. Gould(1), James I. MacRae(1)