Robert Blassberg

Discovery Centre — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index850citations19works4.02yr avg
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Research Topics

Pluripotent Stem Cells Research(7), Developmental Biology and Gene Regulation(6), Epigenetics and DNA Methylation(5), CRISPR and Genetic Engineering(5), Hedgehog Signaling Pathway Studies(5)

Publications19 total

Minimal activation of the p53 DNA damage response by a modular cytosine base editor enables effective multiplexed gene knockout in induced pluripotent stem cells
2025Open Access
An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
Molecular Therapy·2024· 12 citedOpen Access
DEVELOPMENT OF THE PIN-POINTTM PLATFORM: A VERSATILE BASE EDITING TECHNOLOGY WITH BROAD CAS ENZYME AND DEAMINASE COMPATIBILITY FOR CELL AND GENE THERAPY
Cytotherapy·2024
An aptamer-mediated base editing platform for simultaneous knock-in and multiple gene knockout for allogeneic CAR-T cells generation
2023· 1 citedOpen Access
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
Nature Cell Biology·2022· 86 citedOpen Access
Genome Editing of Pluripotent Stem Cells for Adoptive and Regenerative Cell Therapies
GEN Biotechnology·2022· 1 cited
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions
Cell Systems·2021· 138 citedOpen Access
A quantitative landscape of cell fate transitions identifies principles of cellular decision-making
2021· 7 citedOpen Access
Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation
2020· 15 citedOpen Access
TRF2-independent chromosome end protection during pluripotency
Nature·2020· 62 citedOpen Access
Smoothened Sensor Places Sodium and Sterols Center Stage
Developmental Cell·2018· 2 citedOpen Access
Lipid metabolism fattens up hedgehog signaling
BMC Biology·2017· 62 citedOpen Access
Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome
Human Molecular Genetics·2015· 97 citedOpen Access
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
Nature Communications·2015· 161 citedOpen Access
THE LINK BETWEEN CHOLESTEROL AND HEDGEHOG SIGNALLING IN EPILEPSY AND AUTISM SPECTRUM DISORDER: A CELLULAR MODEL OF SMITH-LEMLI-OPITZ SYNDROME
Epilepsia·2015
Morphogen interpretation: the transcriptional logic of neural tube patterning
Current Opinion in Genetics & Development·2013· 99 cited
<i>PBX/extradenticle</i> is required to re-establish axial structures and polarity during planarian regeneration
Development·2013· 55 citedOpen Access
Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration
Journal of Cell Science·2010· 52 citedOpen Access
The mechanism of signal transduction by the GPI anchored Prod 1 protein
UCL Discovery (University College London)·2010

Frequent Co-authors

James Briscoe(9), Immacolata Porreca(4), Olga Mielczarek(4), John Lambourne(3), M. Cohen(2), Meritxell Sáez(2), Elena Camacho-Aguilar(2), Eric D. Siggia(2), D.A.J. Rand(2), John Jacob(2), Harshil Patel(2), Thomas Watson(2), Mina Gouti(2), Vicki Metzis(2), M. Joaquina Delás(2), Jennifer Harbottle(2), Deividas Pazeraitis(2), Julia Liz Touza(2), Tommaso Selmi(2), Žaklina Strezoska(2)