Chien‐Lun Hung

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index183citations15works1.42yr avg
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Research Topics

Electron Spin Resonance Studies(8), Cell death mechanisms and regulation(4), Protein Structure and Dynamics(3), Chronic Lymphocytic Leukemia Research(3), RNA Interference and Gene Delivery(2)

Publications15 total

BTK autoinhibition analyzed by high-throughput swaps of SH2 domains
Proceedings of the National Academy of Sciences·2025Open Access
Electrostatic Clamp and Loop Dynamics Dictate Caspase-8 Cleavage of the Apoptotic Protein Bid
The Journal of Physical Chemistry Letters·2025· 1 citedOpen Access
Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib
Science Signaling·2025· 1 cited
BTK Autoinhibition Analyzed by High-Throughput SH2 Domain Swaps
2025· 1 citedOpen Access
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines
Science Signaling·2025· 4 citedOpen Access
Local Structural Stability of the Acyl-Coenzyme A Binding Protein by ESR Spectroscopy
Applied Magnetic Resonance·2022· 3 cited
Location of the cross‐β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy
Protein Science·2022· 3 citedOpen Access
Simple Cryoprotectant-Free Method to Advance Pulsed Dipolar ESR Spectroscopy for Capturing Protein Conformational Ensembles
The Journal of Physical Chemistry B·2022· 2 cited
Protein Stability Depends Critically on the Surface Hydrogen-Bonding Network: A Case Study of Bid Protein
The Journal of Physical Chemistry B·2021· 23 cited
Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes
Cell Death and Differentiation·2021· 35 citedOpen Access
PEGylation-based strategy to identify pathways involved in the activation of apoptotic BAX protein
Biochimica et Biophysica Acta (BBA) - General Subjects·2020· 5 cited
Doubly spin-labeled nanodiscs to improve structural determination of membrane proteins by ESR
RSC Advances·2019· 9 citedOpen Access
Accessing local structural disruption of Bid protein during thermal denaturation by absorption-mode ESR spectroscopy
RSC Advances·2018· 8 citedOpen Access
Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion
Structure·2015· 48 cited
BAX-Induced Apoptosis Can Be Initiated through a Conformational Selection Mechanism
Structure·2014· 40 citedOpen Access

Frequent Co-authors

Yun‐Wei Chiang(11), Su Wei Lee(4), Jay T. Groves(4), John Kuriyan(4), Timothy J. Eisen(3), Sam Ghaffari-Kashani(3), Tai-Ching Sung(2), Yei‐Chen Lai(2), Hsin-Ho Chang(2), Yun‐Hsuan Kuo(2), Yu-Jing Lan(2), Ching-Yu Li(1), Orion Shih(1), Yi‐Qi Yeh(1), U‐Ser Jeng(1), Chia-Jung Tsai(1), Sophia Liu(1), Siao-Ru Jhong(1), Chieh-Chin Li(1), Pei-Shan Yeh(1)