S. Whitney Barnes

Genomics Institute of the Novartis Research Foundation — United States

Medicine · Health Sciences

21h-index3.5kcitations37works17.52yr avg
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Research Topics

Tuberculosis Research and Epidemiology(8), Antibiotic Resistance in Bacteria(6), Mycobacterium research and diagnosis(5), Malaria Research and Control(4), Bacterial Genetics and Biotechnology(4)

Publications37 total

Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids
Communications Biology·2025· 1 citedOpen Access
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
Science·2024· 66 cited
A high throughput cell stretch device for investigating mechanobiology <i>in vitro</i>
APL Bioengineering·2024· 3 citedOpen Access
AHR activation accelerates the resolution of TGF-β1 induced fibroblast activation and promotes alveolar type 1 cell regeneration in alveolar organoids
2024Open Access
Targeted Degradation of the Wiz Transcription Factor for Gamma Globin De-Repression
Blood·2023· 7 cited
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
Science·2023· 36 citedOpen Access
A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening
PLoS ONE·2023· 7 citedOpen Access
A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma
APL Bioengineering·2023· 3 citedOpen Access
A high-throughput COPD bronchosphere model for disease-relevant phenotypic compound screening
2022Open Access
“3D, human renal proximal tubule (RPTEC-TERT1) organoids ‘tubuloids’ for translatable evaluation of nephrotoxins in high-throughput”
PLoS ONE·2022· 6 citedOpen Access
A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma
2022Open Access
Mutations Reducing <i>In Vitro</i> Susceptibility to Novel LpxC Inhibitors in <i>Pseudomonas aeruginosa</i> and Interplay of Efflux and Nonefflux Mechanisms
Antimicrobial Agents and Chemotherapy·2019· 5 citedOpen Access
Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling
Virology·2019· 16 cited
Defects in Efflux ( <i>oprM</i> ), β-Lactamase ( <i>ampC</i> ), and Lipopolysaccharide Transport ( <i>lptE</i> ) Genes Mediate Antibiotic Hypersusceptibility of <i>Pseudomonas aeruginosa</i> Strain Z61
Antimicrobial Agents and Chemotherapy·2019· 8 citedOpen Access
Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in <i>Pseudomonas aeruginosa</i> PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression
Antimicrobial Agents and Chemotherapy·2018· 19 citedOpen Access
Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells
Nature Methods·2018· 85 cited
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Nature·2016· 407 citedOpen Access
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
PLoS Pathogens·2015· 67 citedOpen Access
KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
Antimicrobial Agents and Chemotherapy·2014· 154 citedOpen Access
Fitness costs of rifampicin resistance in <scp><i>M</i></scp><i>ycobacterium tuberculosis</i> are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of <scp>RNA</scp> polymerase
Molecular Microbiology·2014· 98 citedOpen Access
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Frequent Co-authors

John R. Walker(21), Richard Glynne(9), Glenn C. Federe(7), John R. Walker(7), Arnab K. Chatterjee(6), Kelli Kuhen(5), William R. Jacobs(5), Charles R. Dean(5), Doug Quackenbush(5), Elizabeth A. Winzeler(4), Serge Batalov(4), Adriana K. Jones(4), Angela Woods(4), Pranjali Beri(4), Olivia Ross(4), A. S. Nagle(3), Casey J. N. Mathison(3), Srinivasa P. S. Rao(3), David Plouffe(3), Rachel Borboa(3)