Lars K. Nielsen

University of Queensland — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

77h-index20.2kcitations473works3.02yr avg
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Research Topics

Microbial Metabolic Engineering and Bioproduction(154), Viral Infectious Diseases and Gene Expression in Insects(100), Biofuel production and bioconversion(78), Metabolomics and Mass Spectrometry Studies(35), Gene Regulatory Network Analysis(31)

Publications466 total

Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli
PLoS Pathogens·2025· 1 citedOpen Access
Resolving Single-Cell Gene Expression by Pseudotemporal Integration of Transcriptomic and Proteomic Datasets
Molecular & Cellular Proteomics·2025Open Access
Targeted UDP-glucose ceramide glucosyltransferase stable overexpression induces a metabolic switch improving cell performance at high cell density
Frontiers in Bioengineering and Biotechnology·2025Open Access
Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Chemical Engineering Science·2025· 1 citedOpen Access
A Robust Isotope Ratio LC-MS/MS Workflow for High-Throughput Metabolic Profiling of Bacteria
2025· 1 citedOpen Access
Creatine Supplementation in Heart Failure: A Systematic Review of Functional and Symptomatic Outcomes
Heart Lung and Circulation·2025
Comparative Genomic Assessment of the <scp> <i>Cupriavidus necator</i> </scp> Species for One‐Carbon Based Biomanufacturing
Microbial Biotechnology·2025· 1 citedOpen Access
Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production
Gene Therapy·2025Open Access
Dynamic guessing for Hamiltonian Monte Carlo with embedded numerical root-finding
arXiv (Cornell University)·2025Open Access
Bayesian Independent Component Analysis reconstructs independent modules of gene expression
2025Open Access
Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration
ACS Synthetic Biology·2025· 4 citedOpen Access
A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells
2025· 2 cited
A Diverse Genetic Basis for Metabolic Reactions is Revealed Through Pangenome analysis
2025· 3 citedOpen Access
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells
Nature Metabolism·2025· 15 citedOpen Access
Healthcare institutions and systems
Elsevier eBooks·2025
Systematic insights into cell density-dependent transcriptional responses upon medium replacements
Biomedicine & Pharmacotherapy·2024Open Access
Unsupervised learning bioreactor regimes
Computers & Chemical Engineering·2024· 6 citedOpen Access
Single‐Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies
Biotechnology Journal·2024· 6 citedOpen Access
Unlocking DOE potential by selecting the most appropriate design for rAAV optimization
Molecular Therapy — Methods & Clinical Development·2024· 6 citedOpen Access
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells
2024· 2 citedOpen Access
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Frequent Co-authors

Lake‐Ee Quek(12), Esteban Marcellin(8), Mark P. Hodson(7), Tim R. Mercer(7), Nicholas Timmins(6), Robin Palfreyman(6), Stefanie Dietmair(6), John S. Mattick(6), Peter P. Gray(5), Jens O. Krömer(5), Michael B. Clark(5), Claudia E. Vickers(5), Michael Köpke(5), Cristiana Gomes de Oliveira Dal’Molin(4), Marion E. G. Brunck(4), Joanna Crawford(4), Marcel E. Dinger(4), Kaspar Valgepea(4), Renato de Souza Pinto Lemgruber(4), Séan D. Simpson(4)