Linda S. Wicker

Centre for Human Genetics — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

69h-index18.9kcitations280works23.02yr avg
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Research Topics

Diabetes and associated disorders(156), T-cell and B-cell Immunology(121), Immune Cell Function and Interaction(108), Pancreatic function and diabetes(95), Diabetes Management and Research(38)

Publications280 total

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
Diabetologia·2024· 23 citedOpen Access
Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues
2023· 2 citedOpen Access
SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile
Genome Medicine·2023· 39 citedOpen Access
Gene expression signature predicts rate of type 1 diabetes progression
EBioMedicine·2023· 18 citedOpen Access
Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells
Nature Communications·2023· 38 citedOpen Access
CD56bright natural killer cells preferentially kill proliferating CD4+ T cells
Discovery Immunology·2023· 13 citedOpen Access
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Nature Communications·2022· 31 citedOpen Access
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes
Trials·2022· 37 citedOpen Access
Autoimmune interactions between the HLA-DQβ1 <sub>57</sub> polymorphism, T cell receptors, and microbial mimics of insulin in type 1 diabetes
2022· 2 citedOpen Access
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus
Wellcome Open Research·2022· 14 citedOpen Access
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration
Diabetes·2022· 37 citedOpen Access
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration
2022Open Access
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration
2022Open Access
Low-dose IL-2 reduces IL-21 <sup>+</sup> T cells and induces a long-lived anti-inflammatory gene expression signature inversely modulated in COVID-19 patients
2022· 2 citedOpen Access
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
2021Open Access
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Communications Biology·2021· 45 citedOpen Access
HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection
2021· 3 citedOpen Access
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Nature Genetics·2021· 284 cited
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus
Wellcome Open Research·2021· 7 citedOpen Access
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus
2021Open Access
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Frequent Co-authors

John A. Todd(29), Laurence B. Peterson(25), Neil Walker(9), Paul Lyons(9), Deborah J. Smyth(7), Kara Hunter(6), Barry Healy(6), Patricia L. Podolin(6), Natasha Hill(6), Joanna M. M. Howson(5), Luc J Smink(5), Jason D. Cooper(5), Jan‐Bas Prins(5), Nicole H. DeLarato(5), Marcin Ł. Pękalski(5), Antony J. Cutler(5), Paul Denny(5), Christopher J. Lord(5), Sarah Nutland(4), David Clayton(4)