Deborah J. Smyth

Wellcome Sanger Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

55h-index18.6kcitations107works0.02yr avg
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Research Topics

Diabetes and associated disorders(61), Immune Cell Function and Interaction(29), Pancreatic function and diabetes(28), T-cell and B-cell Immunology(27), Diabetes Management and Research(14)

Publications106 total

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
Nature Genetics·2022· 164 citedOpen Access
Immune disease variants modulate gene expression in regulatory CD4+ T cells
Cell Genomics·2022· 60 citedOpen Access
Immune disease variants modulate gene expression in regulatory CD4+ T cells
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Immune disease variants modulate gene expression in regulatory CD4+ T cells
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
Zenodo (CERN European Organization for Nuclear Research)·2022· 1 citedOpen Access
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
2021· 16 citedOpen Access
Multiplex melanoma families are enriched for polygenic risk
Human Molecular Genetics·2020· 10 citedOpen Access
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Nature Communications·2020· 302 citedOpen Access
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Nature Genetics·2019· 144 cited
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
2019· 27 citedOpen Access
Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets
2019· 13 citedOpen Access
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
2019· 11 citedOpen Access
Increased sporulation underpins adaptation of Clostridium difficile strain 630 to a biologically–relevant faecal environment, with implications for pathogenicity
Scientific Reports·2018· 379 citedOpen Access
Inactivation of the dnaK gene in Clostridium difficile 630 Δerm yields a temperature-sensitive phenotype and increases biofilm-forming ability
Scientific Reports·2017· 42 citedOpen Access
Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
Wellcome Open Research·2017· 23 citedOpen Access
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
JCI Insight·2017· 68 citedOpen Access
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity
Journal of Autoimmunity·2017· 90 citedOpen Access
Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
Wellcome Open Research·2017· 1 citedOpen Access
Cells with Treg-specific <i>FOXP3</i> demethylation but low CD25 are prevalent in autoimmunity
2017· 2 citedOpen Access
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Frequent Co-authors

John A. Todd(44), Neil Walker(32), Joanna M. M. Howson(20), Chris Wallace(17), David Clayton(16), Jason D. Cooper(16), Linda S. Wicker(11), David B. Dunger(11), Vincent Plagnol(9), Helen Stevens(9), Ricardo C. Ferreira(9), Marcin Ł. Pękalski(9), Oliver S. Burren(8), Antony J. Cutler(8), Sarah Nutland(7), Helen E. Stevens(7), Stephen S. Rich(6), Kate Downes(6), Jennie H. M. Yang(6), Jason D. Cooper(6)