Glenys A. Tennent

University College London — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index5.9kcitations63works0.02yr avg
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Research Topics

Amyloidosis: Diagnosis, Treatment, Outcomes(32), Alzheimer's disease research and treatments(19), Pancreatitis Pathology and Treatment(9), Parathyroid Disorders and Treatments(8), Drug Transport and Resistance Mechanisms(6)

Publications63 total

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
Nature Communications·2021· 34 citedOpen Access
Amyloid damage to islet β-cells in type 2 diabetes: hypoxia or pseudo-hypoxia?
2019· 5 citedOpen Access
Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits<i>in vivo</i>
Open Biology·2016· 27 citedOpen Access
Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction
Cell Reports·2015· 158 citedOpen Access
Bifunctional crosslinking ligands for transthyretin
Open Biology·2015· 2 citedOpen Access
Clinical characteristics and SAP scintigraphic findings in 10 patients with AGel amyloidosis
Amyloid·2014· 6 cited
C‐reactive protein is essential for innate resistance to pneumococcal infection
Immunology·2014· 42 citedOpen Access
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis
Proceedings of the National Academy of Sciences·2014· 121 citedOpen Access
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use
Journal of Immunological Methods·2012· 36 citedOpen Access
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
Proceedings of the National Academy of Sciences·2010· 65 citedOpen Access
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
Nature·2010· 329 citedOpen Access
Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis
British Journal of Haematology·2010· 130 citedOpen Access
A Common β-Sheet Architecture Underlies in Vitro and in Vivo β2-Microglobulin Amyloid Fibrils
Journal of Biological Chemistry·2008· 63 citedOpen Access
Reply
Arthritis & Rheumatism·2007· 1 cited
Molecular Mechanisms of Fibrillogenesis and the Protective Role of Amyloid P Component: Two Possible Avenues for Therapy
Novartis Foundation symposium·2007· 15 cited
Production and Characterization of RNA Aptamers Specific for Amyloid Fibril Epitopes
Journal of Biological Chemistry·2007· 40 citedOpen Access
Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE−/− mice
Atherosclerosis·2007· 97 cited
Normal circulating serum amyloid P component concentration in systemic sclerosis
Arthritis & Rheumatism·2007· 14 cited
Lysine 58‐cleaved β2‐microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis‐related amyloidosis
Protein Science·2007· 24 citedOpen Access
Is leptin an important physiological regulator of CRP?
Nature Medicine·2007· 15 cited
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Frequent Co-authors

Mark B. Pepys(35), Philip N. Hawkins(19), J. Ruth Gallimore(12), Winston L. Hutchinson(8), Melvyn Kahan(6), Vittorio Bellotti(6), Graham W. Taylor(6), Julian D. Gillmore(6), Caroline Sabin(5), P. Patrizia Mangione(5), Carol V. Robinson(4), W. L. Hutchinson(4), Stéphan Ellmerich(4), David J. Millar(4), S E Booth(4), Sheena E. Radford(4), M B Pepys(4), David R. Booth(4), Gideon M. Hirschfield(3), Simon Kolstoe(3)