Winston L. Hutchinson

University College London — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index5.0kcitations31works0.02yr avg
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Research Topics

Amyloidosis: Diagnosis, Treatment, Outcomes(9), Alzheimer's disease research and treatments(7), Adipokines, Inflammation, and Metabolic Diseases(7), Drug Transport and Resistance Mechanisms(5), Trace Elements in Health(5)

Publications31 total

C‐reactive protein is essential for innate resistance to pneumococcal infection
Immunology·2014· 42 citedOpen Access
Pathogenetic mechanisms of amyloid A amyloidosis
Proceedings of the National Academy of Sciences·2013· 115 citedOpen Access
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use
Journal of Immunological Methods·2012· 36 citedOpen Access
Immunoradiometric assay for human serum amyloid P component
Journal of Immunological Methods·2011· 7 cited
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
Nature·2010· 329 citedOpen Access
Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis
British Journal of Haematology·2010· 130 citedOpen Access
Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component
Proceedings of the National Academy of Sciences·2009· 65 citedOpen Access
P2‐307: CPHPC depletes serum amyloid P component from the cerebrospinal fluid in Alzheimer's disease
Alzheimer s & Dementia·2008
Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE−/− mice
Atherosclerosis·2007· 97 cited
Calcium dependent by pentraxins to ligands immobilized on agarose, and effect of C-reactive protein on leptin action in mice in vivo
Protocol Exchange·2007
Is leptin an important physiological regulator of CRP?
Nature Medicine·2007· 15 cited
Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
Proceedings of the National Academy of Sciences·2005· 192 citedOpen Access
Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice
Immunology·2004· 3 citedOpen Access
Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
Immunology·2004· 62 citedOpen Access
Determination of C-Reactive Protein: Comparison of Three High-Sensitivity Immunoassays
Clinical Chemistry·2003· 30 citedOpen Access
Lack of Seasonal Variation in C-Reactive Protein
Clinical Chemistry·2002· 45 citedOpen Access
Influenza Virus Infection is not Affected by Serum Amyloid P Component
Molecular Medicine·2002· 14 citedOpen Access
Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population
Clinical Chemistry·2000· 252 cited
Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum
Molecular Medicine·2000· 67 citedOpen Access
C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men
Circulation·1999· 1.9k citedOpen Access
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Frequent Co-authors

Mark B. Pepys(17), Philip N. Hawkins(8), Glenys A. Tennent(8), J. Ruth Gallimore(8), Mark B. Pepys(5), David J. Millar(5), Wolfgang Köenig(4), Stéphan Ellmerich(4), Jeff Herbert(4), M. Sund(3), Margit Fröhlich(3), Vittorio Bellotti(3), Melvyn Kahan(3), P. Patrizia Mangione(3), Amar P. Dhillon(3), Aviva Petrie(3), Julian D. Gillmore(3), Marina Botto(3), Caroline Sabin(3), Ming‐Qing Du(3)