Hye Yun Kim

Yonsei University — South Korea

Medicine · Health Sciences

26h-index3.3kcitations109works10.12yr avg
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Research Topics

Alzheimer's disease research and treatments(59), Cholinesterase and Neurodegenerative Diseases(30), Neuroscience and Neuropharmacology Research(18), Computational Drug Discovery Methods(17), Neuroinflammation and Neurodegeneration Mechanisms(9)

Publications109 total

Tau Repeats Disassemble Amyloid-β Fibrils <i>In Vitro</i> by Interacting with KLVFFA and GGVVIA Domains
ACS Chemical Neuroscience·2025
Charge Modification of Lysine Mitigates Amyloid‐β Aggregation
ChemBioChem·2025· 1 cited
Aryloxypropanolamine mitigates Alzheimer‐like phenotype by directly removing amyloid aggregates
Alzheimer s & Dementia·2024Open Access
Benzofuroisoquinoline derivatives reverse amyloidogenesis and amyloid‐associated memory impairments in acute and transgenic mouse models of Alzheimer’s disease
Alzheimer s & Dementia·2024Open Access
The mapping of active sites of amyloid‐targeting compounds through the utilization of immobilized fragments of amyloid hexamers
Alzheimer s & Dementia·2024Open Access
Chemical-Driven Amyloid Clearance for Therapeutics and Diagnostics of Alzheimer’s Disease
Accounts of Chemical Research·2024· 7 cited
Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers
Angewandte Chemie·2024· 1 citedOpen Access
Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers
Angewandte Chemie International Edition·2024· 5 citedOpen Access
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta
Journal of Neuroinflammation·2024· 17 citedOpen Access
Modulation of Amyloid and Tau Aggregation to Alleviate Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
ACS Pharmacology & Translational Science·2024· 1 citedOpen Access
Chemically Driven Clearance of Amyloid Aggregates by Polyfunctionalized Furo[2,3-<i>b</i>:4,5-<i>b</i>′]dipyridine–Chalcone Hybrids to Ameliorate Memory in an Alzheimer Mouse Model
Molecular Pharmaceutics·2024· 1 cited
Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid
Nature Communications·2024· 88 citedOpen Access
PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III
Experimental & Molecular Medicine·2023· 6 citedOpen Access
Benzo[<i>d</i>]imidazole-pyrrolo[1,2-<i>a</i>]pyrazine Hybrids Ameliorate Amyloid Aggregates in the Brain of Alzheimer Transgenic Mice
ACS Chemical Neuroscience·2023· 9 cited
Failure, Success, and Future Direction of Alzheimer Drugs Targeting Amyloid‐β Cascade: Pros and Cons of Chemical and Biological Modalities
ChemBioChem·2023· 12 cited
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
Scientific Reports·2023· 7 citedOpen Access
4-Acyl-3,4-dihydropyrrolo[1,2-<i>a</i>]pyrazine Derivative Rescued the Hippocampal-Dependent Cognitive Decline of 5XFAD Transgenic Mice by Dissociating Soluble and Insoluble Aβ Aggregates
ACS Chemical Neuroscience·2023· 6 cited
Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine Bacillus sp.
Marine Drugs·2023· 3 citedOpen Access
Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β3-42 peptide
Scientific Reports·2023· 8 citedOpen Access
Immobilized Amyloid Hexamer Fragments to Map Active Sites of Amyloid-Targeting Chemicals
ACS Chemical Neuroscience·2022· 12 citedOpen Access
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Frequent Co-authors

Young Soo Kim(36), Kyeonghwan Kim(9), Jisu Shin(7), C. Justin Lee(6), Hyunjin Vincent Kim(6), Illhwan Cho(6), Sejin Lee(6), Dong-Hee Lee(6), Soljee Yoon(6), Seonmi Jo(5), Dong Jin Kim(5), Seungyeop Baek(5), Dong Ho Woo(4), Jae‐Ick Kim(4), Seung‐Hoon Yang(4), Soo‐Jin Oh(3), Seon Young Choi(3), Hyunjin V. Kim(3), Soo Min Cho(3), Dongkeun K. Lee(3)