Ryan T. Strachan

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index5.0kcitations47works1.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(30), Neuropeptides and Animal Physiology(18), Monoclonal and Polyclonal Antibodies Research(8), Neurotransmitter Receptor Influence on Behavior(6), Protein Kinase Regulation and GTPase Signaling(3)

Publications47 total

Investigating the effectiveness of commercially available mouthwash on SARS-CoV-2 in vivo using viable virus titre as the primary outcome. A randomised controlled trial
Access Microbiology·2024· 2 citedOpen Access
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
Carolina Digital Repository (University of North Carolina at Chapel Hill)·2024Open Access
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
Biochemistry·2023· 63 cited
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
2022· 6 citedOpen Access
Structure-Based Design of a Chemical Probe Set for the 5-HT <sub>5A</sub> Serotonin Receptor
Journal of Medicinal Chemistry·2022· 29 citedOpen Access
Structure-based design of a chemical probe set for the 5-HT <sub>5A</sub> serotonin receptor
2021Open Access
Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT 2A ) Serotonin Receptor, Thereby Modulating 5-HT 2A Signaling
UNC Libraries·2020Open Access
p90 Ribosomal S6 Kinase 2, a Novel GPCR Kinase, Is Required for Growth Factor-Mediated Attenuation of GPCR Signaling
Figshare·2020Open Access
Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
Figshare·2020Open Access
Erratum: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells (Cell (2019) 178(3) (748–761.e17), (S0092867419306221), (10.1016/j.cell.2019.05.051))
UNC Libraries·2020Open Access
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Nature Chemical Biology·2020· 532 citedOpen Access
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
UNC Libraries·2020Open Access
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
UNC Libraries·2020Open Access
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Cell·2019· 251 citedOpen Access
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
Cell·2019· 19 citedOpen Access
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
Cell·2019· 103 citedOpen Access
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Trends in Pharmacological Sciences·2018· 63 cited
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Cell·2018· 362 citedOpen Access
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling
JCI Insight·2017· 42 citedOpen Access
Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry Syndrome
2017· 2 citedOpen Access
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Frequent Co-authors

Bryan L. Roth(22), Robert J. Lefkowitz(13), Seungkirl Ahn(11), Alem W. Kahsai(7), Biswaranjan Pani(7), Dean P. Staus(7), Laura M. Wingler(7), Reid H. J. Olsen(6), Samuel T. Slocum(5), Els Pardon(5), Jan Steyaert(5), Douglas J. Sheffler(5), Justin G. English(4), B. Krumm(4), Daniel Wacker(4), Brian K. Kobilka(4), Tommaso Costa(4), Brian K. Shoichet(4), Terry Kenakin(4), Sudha K. Shenoy(3)