Sudha K. Shenoy

Duke University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index14.3kcitations106works0.82yr avg
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Research Topics

Receptor Mechanisms and Signaling(70), Neuropeptides and Animal Physiology(33), Ubiquitin and proteasome pathways(23), Protein Degradation and Inhibitors(13), Protein Kinase Regulation and GTPase Signaling(11)

Publications106 total

Emerging roles of ubiquitin-specific proteases in the cardiovascular system
Molecular Pharmacology·2025
Inflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20
2025Open Access
USP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality
American Journal of Physiology-Heart and Circulatory Physiology·2024· 4 citedOpen Access
Abstract Or110: Inflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20
Circulation Research·2024
Molecular Determinants of Beta-Arrestin Binding to the Glucagon Receptor
Journal of Pharmacology and Experimental Therapeutics·2024
Editorial: Regulation of hormone and growth factor signalling by ubiquitin and ubiquitin-like protein modifications
Frontiers in Endocrinology·2024· 1 citedOpen Access
How carvedilol does not activate β2-adrenoceptors
Nature Communications·2023· 11 citedOpen Access
β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure
Current Opinion in Physiology·2023· 8 citedOpen Access
An insulin-regulated arrestin domain protein controls hepatic glucagon action
Journal of Biological Chemistry·2023· 16 citedOpen Access
Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation
Journal of Biological Chemistry·2023· 12 citedOpen Access
The ubiquitination status of the glucagon receptor determines signal bias
Journal of Biological Chemistry·2023· 9 citedOpen Access
A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein–coupled receptors
Journal of Biological Chemistry·2022· 4 citedOpen Access
Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling
Journal of Biological Chemistry·2020· 21 citedOpen Access
SnapShot: β-Arrestin Functions
Cell·2020· 49 citedOpen Access
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
Cellular Signalling·2020· 7 citedOpen Access
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection
UNC Libraries·2020Open Access
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs
ACS Pharmacology & Translational Science·2019· 12 citedOpen Access
Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET
Methods in molecular biology·2019· 6 cited
The deubiquitinase ubiquitin–specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling
Journal of Biological Chemistry·2018· 25 citedOpen Access
USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology·2018· 49 citedOpen Access
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Frequent Co-authors

Robert J. Lefkowitz(32), Seungkirl Ahn(12), Kunhong Xiao(11), Pierre‐Yves Jean‐Charles(7), Arun K. Shukla(6), Matthew T. Drake(5), Erin J. Whalen(5), Neil J. Freedman(5), Reddy Peera Kommaddi(5), Louis M. Luttrell(4), Sudarshan Rajagopal(4), James W. Wisler(4), Jonathan D. Violin(4), Jiao‐Hui Wu(4), Leigh Brian(4), Scott M. DeWire(3), Ryan T. Strachan(3), Makoto R. Hara(3), Suneet Kaur(3), Ji‐Hee Kim(3)