James W. Wisler

Duke Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.6kcitations23works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Neuropeptides and Animal Physiology(4), Atrial Fibrillation Management and Outcomes(2), Venous Thromboembolism Diagnosis and Management(2), Aortic Disease and Treatment Approaches(2)

Publications23 total

The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility
Proceedings of the National Academy of Sciences·2020· 38 citedOpen Access
Disrupting Fellow Education Through Group Texting
Journal of the American College of Cardiology·2018· 30 cited
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Skeletal Muscle·2018· 51 citedOpen Access
Biased G Protein–Coupled Receptor Signaling
Circulation·2018· 96 citedOpen Access
β-Arrestin2 mediates progression of murine primary myelofibrosis
JCI Insight·2017· 8 citedOpen Access
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
Nature Chemical Biology·2016· 80 citedOpen Access
β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis
Blood·2015
The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome
American Journal of Physiology-Heart and Circulatory Physiology·2015· 20 citedOpen Access
Antithrombotic therapy: new areas to understand efficacy and bleeding
Expert Opinion on Therapeutic Targets·2014· 6 cited
NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME
Journal of the American College of Cardiology·2014
Recent developments in biased agonism
Current Opinion in Cell Biology·2013· 279 citedOpen Access
Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia
Blood·2013
Emerging paradigms in arterial thrombosis
Journal of Thrombosis and Thrombolysis·2013· 8 cited
MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors
The Journal of Cell Biology·2012· 62 citedOpen Access
Challenges and Opportunities in Implementing Pharmacogenomics Testing in the Clinics
Personalized Medicine·2012
A Guidance Pathway for the Selection of Novel Anticoagulants in the Treatment of Atrial Fibrillation
Critical Pathways in Cardiology A Journal of Evidence-Based Medicine·2012· 7 cited
Oral factor Xa inhibitors for the long-term management of ACS
Nature Reviews Cardiology·2012· 6 cited
Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia
Journal of Thrombosis and Thrombolysis·2012· 11 cited
The Diversity of Wound Presentation Associated With Freon Contact Frostbite Injury
Journal of Burn Care & Research·2010· 7 cited
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
Journal of Biological Chemistry·2007· 253 citedOpen Access
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Frequent Co-authors

Robert J. Lefkowitz(12), Howard A. Rockman(5), Ji‐Hee Kim(5), Sudha K. Shenoy(4), Lan Mao(4), Erin J. Whalen(3), Jonathan D. Violin(3), Matthew T. Drake(3), Seungkirl Ahn(3), Minyong Chen(3), Wei Chen(3), Lindsay Rein(3), Barbara S. Theriot(3), Richard T. Premont(3), Richard C. Becker(3), Scott M. DeWire(2), Kunhong Xiao(2), A. Thomsen(2), Laura M. Wingler(2), Chad A. Grotegut(2)