Scott M. DeWire

Bipar — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index4.7kcitations26works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(15), Neuropeptides and Animal Physiology(11), Viral-associated cancers and disorders(7), Herpesvirus Infections and Treatments(6), Cytomegalovirus and herpesvirus research(6)

Publications26 total

Data Management and Sharing Plan for: Targeting EBV-associated lymphomas
UNC Dataverse·2026Open Access
Data Management and Sharing Plan for: Therapy for Non-Hodgkin lympoma
UNC Dataverse·2026Open Access
Rhesus monkey rhadinovirus (RRV): construction of a RRV-GFP recombinant virus and development of assays to assess viral replication
UNC Libraries·2021Open Access
Unexpected Potency Differences between B-Cell–Activating Factor (BAFF) Antagonist Antibodies against Various Forms of BAFF: Trimer, 60-Mer, and Membrane-Bound
Journal of Pharmacology and Experimental Therapeutics·2016· 20 cited
Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain
Journal of Medicinal Chemistry·2013· 193 citedOpen Access
An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents
Journal of Pain·2013Open Access
A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine
Journal of Pharmacology and Experimental Therapeutics·2013· 631 cited
Biased Ligands for Better Cardiovascular Drugs
Circulation Research·2011· 158 cited
Quantifying Ligand Bias at Seven-Transmembrane Receptors
Molecular Pharmacology·2011· 387 cited
G-Protein-Dependent and -Independent Signaling Pathways and their Impact on Cardiac Function Compartmentalization of b-Adrenergic Signals in Cardiomyocytes G-Protein-Coupled Receptor Kinases (GRK) as Therapeutic Targets in Cardiovascular Disease Regulators of G-Protein Signaling in the Heart and Their Potential as Therapeutic Targets
2011
Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance
Journal of Pharmacology and Experimental Therapeutics·2010· 362 cited
TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure
Journal of Cardiac Failure·2010· 2 cited
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
Journal of Clinical Investigation·2009· 231 citedOpen Access
β-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration
Circulation Research·2008· 112 citedOpen Access
β-Arrestin-mediated Signaling Regulates Protein Synthesis
Journal of Biological Chemistry·2008· 91 citedOpen Access
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
Proceedings of the National Academy of Sciences·2007· 590 citedOpen Access
β-Arrestins and Cell Signaling
Annual Review of Physiology·2007· 1.4k cited
A unique mechanism of -blocker action: Carvedilol stimulates -arrestin signaling
2007· 52 cited
G Protein-coupled Receptor Kinase and β-Arrestin-mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics
Journal of Biological Chemistry·2006· 81 citedOpen Access
Whole-Genome Transcription Profiling of Rhesus Monkey Rhadinovirus
Journal of Virology·2005· 45 citedOpen Access
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Frequent Co-authors

Jonathan D. Violin(12), Robert J. Lefkowitz(8), Blossom Damania(8), Erin J. Whalen(6), Seungkirl Ahn(5), Dennis S. Yamashita(5), David H. Rominger(5), Michael W. Lark(4), Sudha K. Shenoy(3), Michael Koblish(3), Stuart P Krall(3), Conrad L. Cowan(2), Xiaotao Chen(2), Philip Pitis(2), Dimitar B. Gotchev(2), Catherine Yuan(2), James W. Wisler(2), Matthew T. Drake(2), Christopher M. Lam(2), Maxine Gowen(2)