Charles M. Perou

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

193h-index255.3kcitations2.0kworks2.02yr avg

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Research Topics

Cancer Genomics and Diagnostics(446), Breast Cancer Treatment Studies(367), Cancer Cells and Metastasis(259), HER2/EGFR in Cancer Research(220), Cancer Immunotherapy and Biomarkers(186)

Publications1.9k total

Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response

2026Open Access

Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers

Nature Communications·2026Open Access

Asparagine bioavailability governs metastasis in a model of breast cancer

UNC Libraries·2025Open Access

DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer

UNC Libraries·2025Open Access

Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening—Reply

UNC Libraries·2025Open Access

Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes

UNC Libraries·2025Open Access

FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

UNC Libraries·2025Open Access

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

UNC Libraries·2025Open Access

Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer

UNC Libraries·2025Open Access

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast

UNC Libraries·2025Open Access

Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts

UNC Libraries·2025Open Access

Pathological Response and Survival in Triple-Negative Breast Cancer Following Neoadjuvant Carboplatin plus Docetaxel

UNC Libraries·2025Open Access

PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients

UNC Libraries·2025Open Access

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

UNC Libraries·2025Open Access

Tumor Suppressor PLK2 May Serve as a Biomarker in Triple-Negative Breast Cancer for Improved Response to PLK1 TherapeuticsPLK2 as a Biomarker for PLK1 Therapeutics

UNC Libraries·2025Open Access

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy – results from two independent randomized trials

UNC Libraries·2025Open Access

B7-H3 and CSPG4 co-targeting as Pan-CAR-T cell treatment of triple-negative breast cancer

UNC Libraries·2025Open Access

Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities

UNC Libraries·2025Open Access

Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor Heterogeneity.

UNC Libraries·2025Open Access

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

UNC Libraries·2025Open Access

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Frequent Co-authors

Patrick O. Brown(10), David Botstein(10), Joel S. Parker(9), Xiaping He(9), Matt van de Rijn(7), Stefanie S. Jeffrey(7), Katherine A. Hoadley(7), Maggie C.U. Cheang(7), Anne‐Lise Børresen‐Dale(6), Sherri R. Davies(6), Torsten O. Nielsen(6), Matthew J. Ellis(6), Lisa A. Carey(6), Chad Livasy(6), Thérese Sørlie(5), Michael B. Eisen(5), Christian A. Rees(5), Alexander Pergamenschikov(5), Per Eystein Lønning(5), Li Ding(5)