David Botstein

San Francisco VA Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

167h-index221.3kcitations534works31.02yr avg
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Research Topics

Fungal and yeast genetics research(186), Gene expression and cancer classification(73), RNA and protein synthesis mechanisms(63), Bacteriophages and microbial interactions(62), Bioinformatics and Genomic Networks(58)

Publications533 total

Geographic distribution of genetic diversity of <i>Heterocephalus glaber</i> analyzed using whole genome sequencing and a chromosome-scale genome assembly
2025· 1 citedOpen Access
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice
Nature Microbiology·2025· 4 citedOpen Access
Dietary restriction impacts health and lifespan of genetically diverse mice
Nature·2024· 119 citedOpen Access
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
2024Open Access
Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice
2023· 2 citedOpen Access
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
2023· 16 citedOpen Access
Global analysis of the yeast knockout phenome
Science Advances·2023· 27 citedOpen Access
Data from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Information from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Data from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Table S1 from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Table S2 from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Table S2 from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Table S1 from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Supplementary Information from Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
2023Open Access
Global analysis of the yeast knock-out phenome
2022· 3 citedOpen Access
Author response: Novel insights from a multiomics dissection of the Hayflick limit
2021· 1 citedOpen Access
RERG Is a Novel ras -related, Estrogen-regulated and Growth-inhibitory Gene in Breast Cancer
UNC Libraries·2021Open Access
A genome‐scale yeast library with inducible expression of individual genes
Molecular Systems Biology·2021· 72 citedOpen Access
Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin
2021· 2 citedOpen Access
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Frequent Co-authors

Patrick O. Brown(27), Matt van de Rijn(12), Michael B. Eisen(11), Charles M. Perou(10), Stefanie S. Jeffrey(7), Gavin Sherlock(6), Jonathan R. Pollack(6), Thérese Sørlie(5), Christian A. Rees(5), Douglas T. Ross(5), Alexander Pergamenschikov(5), Per Eystein Lønning(5), Robert Tibshirani(5), Ash A. Alizadeh(5), J. Michael Cherry(4), John C. Matese(4), Paul T. Spellman(4), Hilde Johnsen(4), Cheryl F. Williams(4), Anne‐Lise Børresen‐Dale(4)