Helen Y. Figueroa

Columbia University Irving Medical Center — United States

Medicine · Health Sciences

14h-index2.3kcitations26works2.02yr avg
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Research Topics

Alzheimer's disease research and treatments(19), Neuroscience and Neuropharmacology Research(13), Cellular transport and secretion(4), Neuroinflammation and Neurodegeneration Mechanisms(4), Mitochondrial Function and Pathology(3)

Publications26 total

APOE Genotype Modulates Tau Propagation in A Novel Humanized Mouse Model of Early‐Stage Alzheimer's Disease
Alzheimer s & Dementia·2025Open Access
APOE4 Alters Tau Propagation in Regions Associated with Early Alzheimer’s Disease in a Humanized Mouse Model of Tau Spread
Alzheimer s & Dementia·2024Open Access
5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy
Frontiers in Cellular Neuroscience·2024· 6 citedOpen Access
Fractional Factorial Design to Evaluate the Synthesis and Electrochemical Transfer Parameters of h-BN Coatings
Nanomaterials·2023· 3 citedOpen Access
5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy
2023· 2 citedOpen Access
PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Science Translational Medicine·2021· 41 citedOpen Access
Signatures of disrupted synaptic maintenance in the entorhinal cortex of both pathology‐free <i>APOE4</i> carriers and aged <i>APOE4</i> mice
Alzheimer s & Dementia·2020Open Access
Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy
Science Advances·2020· 23 citedOpen Access
Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy
2020· 3 citedOpen Access
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
Scientific Reports·2020· 57 citedOpen Access
GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology <i>in vivo</i>
2020· 2 citedOpen Access
P3‐175: <i>APOE4</i> INDUCES REGION‐SPECIFIC DYSFUNCTION IN THE ENTORHINAL CORTEX OF AGED <i>APOE4</i> MICE
Alzheimer s & Dementia·2019Open Access
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
Nature Neuroscience·2018· 258 citedOpen Access
<i>APOE4</i> is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged <i>APOE</i> Mice
2018Open Access
O2‐01‐04: CELL TYPE–SPECIFIC TAU HOMEOSTASIS SIGNATURES ASSOCIATED WITH SELECTIVE VULNERABILITY OF EXCITATORY NEURONS TO TAU PATHOLOGY
Alzheimer s & Dementia·2018
The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
Frontiers in Neuroscience·2017· 124 citedOpen Access
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
Nature Communications·2017· 191 citedOpen Access
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Neuron·2017· 291 citedOpen Access
3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice
PLoS ONE·2016· 29 citedOpen Access
Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons
Journal of Biological Chemistry·2012· 536 citedOpen Access
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Frequent Co-authors

Karen Duff(22), Mathieu Herman(9), Tal Nuriel(8), Wai Haung Yu(6), Hirra A. Arain(6), Hongjun Fu(5), Emmanuel Planel(5), Mark Cookson(5), Archana Ashok(4), Avery M. Runyan(4), Natura Myeku(4), Sheina Emrani(3), S. Abid Hussaini(3), Stephanie L. Fowler(3), Wen Yi(3), Lili Wang(3), Pavan Krishnamurthy(3), Li Liu(3), Qiuying Chen(3), Christine Fung(3)