Tracy A. Brooks

Binghamton University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.5kcitations76works1.32yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(45), Advanced biosensing and bioanalysis techniques(37), RNA Interference and Gene Delivery(36), Drug Transport and Resistance Mechanisms(9), Monoclonal and Polyclonal Antibodies Research(6)

Publications75 total

Ovarian Cancer Susceptibility and Chemosensitivity to KRAS Modulation
International Journal of Molecular Sciences·2026Open Access
Nonglycosylated, Legumain-Cleavable ISACs Drive Potent Antitumor Immunotherapy via a Bystander Effect
Molecular Cancer Therapeutics·2025Open Access
Dissecting the Efficacy and Immunogenicity of TLR7 Agonist–Antibody Conjugates through the Lens of Fc Effector Function, Conjugation Strategies, and Linker Cleavability
Journal of Medicinal Chemistry·2025Open Access
Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Abstract A112: Breaking BRD4: Tailoring E3 ligase recruitment for tumor-selective MYC suppression in pancreatic cancer
Cancer Research·2025
Resin-Supported Site-Specific Antibody Conjugation Method Leads to Antibody-Drug Conjugates with Retained Efficacy and Improved Stability
Bioconjugate Chemistry·2025· 1 citedOpen Access
Abstract 5834: Discovery of a novel Trop2-targeting immune-stimulating antibody conjugate with efficacy in pancreatic cancer models
Cancer Research·2025
Combinatorial Anti-Cancer Effect of Polypurine Reverse Hoogsteen Hairpins against KRAS and MYC Targeting in Prostate and Pancreatic Cancer Cell Lines
Genes·2024· 2 citedOpen Access
Enhancing Oncology Infographic Evaluation: A Peer Calibration Approach
American Journal of Pharmaceutical Education·2024Open Access
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Xenobiotica·2024· 9 citedOpen Access
Targeting MYC Regulation with Polypurine Reverse Hoogsteen Oligonucleotides
International Journal of Molecular Sciences·2022· 9 citedOpen Access
RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity
International Journal of Molecular Sciences·2022· 6 citedOpen Access
Indoloquinoline-Mediated Targeted Downregulation of KRAS through Selective Stabilization of the Mid-Promoter G-Quadruplex Structure
Genes·2022· 7 citedOpen Access
Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates
Molecular Pharmaceutics·2022· 42 citedOpen Access
Abstract 675: Facilitating G-quadruplex formation in the KRAS promoter with polypurine reverse Hoogsteen oligonucleotides
Cancer Research·2022
Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery
AAPS PharmSciTech·2022· 56 citedOpen Access
Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides
International Journal of Molecular Sciences·2022· 9 citedOpen Access
Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi
Molecules·2021· 4 citedOpen Access
Abstract 1246: Anticancer activitiy of indolo[2,3-c]quinoline stabilization of the KRAS promoter G4mid structure
Cancer Research·2021
Abstract 653: Enhancing therapies for MYC-overexpressing Non-Hodgkin's lymphoma: A role for MYC downregulation and new combination therapies
Cancer Research·2020
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Frequent Co-authors

Laurence H. Hurley(8), Alexandra Maria Psaras(8), Rhianna K. Morgan(7), Thomas P. Davis(6), Randy M. Wadkins(6), Taisen Hao(6), Maria R. Baer(5), Ralph J. Bernacki(5), L. Nathan Tumey(5), Richard D. Egleton(4), Iwao Ojima(4), Melissa J. Seelbach(4), Nicole Nametz(4), Vanessa C. Gaerig(4), Robert V. Brown(3), Vijay Gokhale(3), Hans Minderman(3), Kieran L. O’Loughlin(3), Simonas Valiuska(3), Verónique Noé(3)