Michael E. Bembenek

Takeda (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.6kcitations35works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(6), Cellular transport and secretion(6), Bioactive natural compounds(4), Biotin and Related Studies(4), Neurotransmitter Receptor Influence on Behavior(3)

Publications35 total

Antibody-free detection of cellular neddylation dynamics of Cullin1
Analytical Biochemistry·2018· 6 cited
An ultrasensitive assay format for detecting ULK1 inhibition by monitoring the phosphorylation status of Atg13
Analytical Biochemistry·2016· 1 cited
Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen
Analytical Biochemistry·2013· 8 cited
Analysis of two pharmacodynamic biomarkers using acoustic micro magnetic particles on the ViBE bioanalyzer
Analytical Biochemistry·2010· 12 cited
Determination of complementary antibody pairs using protein A capture with the AlphaScreen assay format
Analytical Biochemistry·2010· 12 cited
MLN8237: an orally active small molecule inhibitor of Aurora A kinase in phase I clinical trials
Cancer Research·2008· 18 cited
Configuration of a Scintillation Proximity Assay for the Activity Assessment of Recombinant Human Adenine Phosphoribosyltransferase
Assay and Drug Development Technologies·2006· 3 cited
Biochemical Assays for High‐throughput Screening
Methods and principles in medicinal chemistry·2006· 4 cited
A Fluorescence-Based Coupling Reaction for Monitoring the Activity of Recombinant Human NAD Synthetase
Assay and Drug Development Technologies·2005· 14 cited
A Homogeneous Scintillation Proximity Format for Monitoring the Activity of Recombinant Human Long-Chain-Fatty-Acyl-CoA Synthetase 5
Assay and Drug Development Technologies·2004· 6 cited
Characterization of the Kinase Domain of the Ephrin-B3 Receptor Tyrosine Kinase Using a Scintillation Proximity Assay
Assay and Drug Development Technologies·2003· 5 cited
Development of a High-Throughput Assay for Two Inositol-Specific Phospholipase Cs Using a Scintillation Proximity Format
Assay and Drug Development Technologies·2003· 6 cited
Monitoring Inositol-Specific Phospholipase C Activity Using a Phospholipid FlashPlate®
SLAS DISCOVERY·1999· 12 citedOpen Access
Identification and Purification of Diphosphoinositol Pentakisphosphate Kinase, Which Synthesizes the Inositol Pyrophosphate Bis(diphospho)inositol Tetrakisphosphate
Biochemistry·1998· 47 cited
Purification and assay of inositol hexakisphosphate kinase and diphosphoinositol pentakisphosphate kinase
1997· 2 cited
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor.
Proceedings of the National Academy of Sciences·1996· 159 cited
The interaction of coatomer with inositol polyphosphates is conserved in <i>Saccharomyces cerevisiae</i>
Biochemical Journal·1995· 46 citedOpen Access
Inhibition of Clathrin Assembly by High Affinity Binding of Specific Inositol Polyphosphates to the Synapse-specific Clathrin Assembly Protein AP-3
Journal of Biological Chemistry·1995· 172 citedOpen Access
Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase
Journal of the American Chemical Society·1992· 35 cited
4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer.
Journal of Biological Chemistry·1992· 93 citedOpen Access
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Frequent Co-authors

Creed W. Abell(9), Arnold Brossi(6), Wieslaw Gessner(5), Thomas F. Parsons(5), William D. Mallender(4), Susan M. Voglmaier(3), Solomon H. Snyder(3), Zhonghua Yan(3), Anne L. Burkhardt(3), Olga Tayber(3), Dongyun Wu(3), Huay-Keng Loke(3), Ping Li(3), Jingya Ma(3), Richard R. Fritz(3), Rebecca Roy(3), Linda Chee(3), Sadhana Jain(3), Allan W. Bach(2), N C Lan(2)