Casey A. Maguire

Northwestern University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index8.3kcitations105works2.42yr avg
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Research Topics

Virus-based gene therapy research(50), RNA Interference and Gene Delivery(38), Extracellular vesicles in disease(24), CRISPR and Genetic Engineering(16), interferon and immune responses(9)

Publications105 total

Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease
Molecular Therapy·2025· 1 citedOpen Access
Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice
Nature Biomedical Engineering·2025· 6 citedOpen Access
Optimizing adsorption elution assays: why antibody saturation matters
Human Immunology·2025
Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve
Gene Therapy·2025
Redosing of AAV vectors in the brain after intracranial injections: Low-ish hanging fruit?
Molecular Therapy — Methods & Clinical Development·2025· 1 citedOpen Access
Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties
Molecular Therapy — Methods & Clinical Development·2025· 2 citedOpen Access
Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV
Metabolic Engineering·2024· 3 citedOpen Access
CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice
Molecular Therapy·2024· 6 citedOpen Access
<i>In vivo</i> Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor
2024· 2 citedOpen Access
An in vitro and in vivo efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs
Molecular Therapy — Methods & Clinical Development·2024· 4 citedOpen Access
Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice
2024Open Access
<scp>AAV</scp> ‐mouse <scp>DNase</scp> I sustains long‐term <scp>DNase</scp> I expression in vivo and suppresses breast cancer metastasis
FASEB BioAdvances·2024· 3 citedOpen Access
Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV.
2024Open Access
In vivo selection in non-human primates identifies AAV capsids for on-target CSF delivery to spinal cord
Molecular Therapy·2024· 9 citedOpen Access
Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2
Molecular Therapy — Methods & Clinical Development·2024Open Access
Issue Information
Annals of Neurology·2024· 1 citedOpen Access
Role of Basal Forebrain Neurons in Adrenomyeloneuropathy in Mice and Humans
Annals of Neurology·2023· 10 citedOpen Access
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Nature Biomedical Engineering·2023· 39 citedOpen Access
<i>In vivo</i> selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord
2023· 2 citedOpen Access
Isolation of Biologically Active Extracellular Vesicles-Associated AAVs for Gene Delivery to the Brain by Size Exclusion Chromatography
2023· 1 citedOpen Access
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Frequent Co-authors

Xandra O. Breakefield(12), Miguel Sena‐Esteves(12), Bakhos A. Tannous(10), Eloïse Hudry(10), Adrienn Volak(9), Bence György(9), Dakai Mu(9), Killian S. Hanlon(8), Zachary Fitzpatrick(7), Bradley T. Hyman(7), David P. Corey(6), Servio H. Ramirez(6), Matheus H. W. Crommentuijn(5), Yi Gong(5), Anat Stemmer‐Rachamimov(5), Shilpa Prabhakar(4), Benjamin P. Kleinstiver(4), Leonora Balaj(4), Johan Skog(4), Carrie Ng(4)