Carrie Ng

Harvard University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index479citations28works2.62yr avg
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Research Topics

Virus-based gene therapy research(13), RNA Interference and Gene Delivery(10), Genetics and Neurodevelopmental Disorders(5), CRISPR and Genetic Engineering(4), Extracellular vesicles in disease(3)

Publications28 total

Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve
Gene Therapy·2025
Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties
Molecular Therapy — Methods & Clinical Development·2025· 2 citedOpen Access
Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV
Metabolic Engineering·2024· 3 citedOpen Access
An in vitro and in vivo efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs
Molecular Therapy — Methods & Clinical Development·2024· 4 citedOpen Access
Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice
2024Open Access
Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV.
2024Open Access
In vivo selection in non-human primates identifies AAV capsids for on-target CSF delivery to spinal cord
Molecular Therapy·2024· 9 citedOpen Access
<i>In vivo</i> selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord
2023· 2 citedOpen Access
An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature
Human Gene Therapy·2023· 21 citedOpen Access
An AAV Encoding Human ABCD1 Shows Dose-Responsive Expression and Function Following Spinal Cord Delivery in a Rodent Model of Adrenomyeloneuropathy (P1-1.Virtual)
Neurology·2022
Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors
Human Gene Therapy·2021· 35 citedOpen Access
Efficient Targeted Transgene Delivery to Injured Lower Motor Neurons
Research Square (Research Square)·2021Open Access
The AAV9 Variant Capsid AAV-F Mediates Widespread Transgene Expression in Nonhuman Primate Spinal Cord After Intrathecal Administration
Human Gene Therapy·2021· 31 citedOpen Access
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
European Journal of Neuroscience·2019· 42 citedOpen Access
Author response for "Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons"
2019
Author response for "Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons"
2019
Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
Molecular Therapy — Methods & Clinical Development·2019· 140 citedOpen Access
Small molecule inhibitors of G9a reactivate the maternal PWS genes in Prader-Willi-Syndrome patient derived neural stem cells and differentiated neurons
2019· 2 citedOpen Access
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
2019· 3 citedOpen Access
Intrathecal Adeno-Associated Viral Vector-Mediated Gene Delivery for Adrenomyeloneuropathy
Human Gene Therapy·2018· 44 citedOpen Access
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Frequent Co-authors

Casey A. Maguire(15), Ming Cheng(8), Demitri de la Cruz(8), Killian S. Hanlon(7), Yi Gong(7), Josette Nammour(7), Paula Espinoza(6), Angela Cacace(5), Owen B. Wallace(5), Miguel C. Santoscoy(5), Joan Aurich‐Costa(5), Florian Eichler(4), John D. Graef(4), Hao Wu(4), Chicheng Sun(4), Deena Qadir(4), Kimberly Jesseman(4), Stephen T. Warren(4), Rudolf Jaenisch(4), Sean W. Clark(4)