Sean W. Clark

Io Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index664citations28works6.52yr avg
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Research Topics

Cellular transport and secretion(10), Lysosomal Storage Disorders Research(9), Virus-based gene therapy research(7), Microtubule and mitosis dynamics(5), Fungal and yeast genetics research(3)

Publications28 total

An in vitro and in vivo efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs
Molecular Therapy — Methods & Clinical Development·2024· 4 citedOpen Access
In vivo selection in non-human primates identifies AAV capsids for on-target CSF delivery to spinal cord
Molecular Therapy·2024· 9 citedOpen Access
<i>In vivo</i> selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord
2023· 2 citedOpen Access
Optimization of intrathecal delivery of an infused AAV9 vector for delivery of a gene therapy candidate for Adrenomyeloneuropathy (AMN) in Non-Human Primates (NHP) (P12-13.008)
Neurology·2022
Preclinical Pharmacology and Toxicology of intrathecally infused AAV9-hABCD1, a gene therapy candidate for AMN, in Non-Human Primates (S29.002)
Neurology·2022
An AAV Encoding Human ABCD1 Shows Dose-Responsive Expression and Function Following Spinal Cord Delivery in a Rodent Model of Adrenomyeloneuropathy (P1-1.Virtual)
Neurology·2022
The <i>GBA1</i> D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models
Disease Models & Mechanisms·2022· 16 citedOpen Access
Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model
PLoS ONE·2021· 40 citedOpen Access
Sanguine Paradise: Effects of Cortisol and Ovarian Hormones on Emotional Memory
2020
Glucosylceramide and Glucosylsphingosine Quantitation by Liquid Chromatography-Tandem Mass Spectrometry to Enable In Vivo Preclinical Studies of Neuronopathic Gaucher Disease
Analytical Chemistry·2017· 28 cited
A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
Neurotherapeutics·2014· 104 citedOpen Access
Glucosylceramide and glucosylsphingosine quantitation by liquid chromotography-tandem mass spectrometry to enable studies of neuronopathic Gaucher disease
Molecular Genetics and Metabolism·2014· 2 cited
The origins of glucosylsphingosine in Gaucher disease
Molecular Genetics and Metabolism·2013· 4 cited
Exploring the Use of Pharmacological Chaperone AT3375 Alone and in Combination with Recombinant human ß-Glucosidase for Gaucher Disease
Molecular Genetics and Metabolism·2012· 3 cited
Glucosylceramide Quantitation in Normal and Glucocerebrosidase-Deficient Mouse Brain and Human Cell Lines
Molecular Genetics and Metabolism·2012· 5 cited
Improved pharmacological chaperones for the treatment of neuronopathic Gaucher and Parkinson's disease
Molecular Genetics and Metabolism·2011
29. Genetic and pharmacological chaperone modulation of brain GCase activity affects synuclein accumulation in mice
Molecular Genetics and Metabolism·2010
Arp10p Is a Pointed-End-associated Component of Yeast Dynactin
Molecular Biology of the Cell·2005· 22 citedOpen Access
Alanine Scanning of Arp1 Delineates a Putative Binding Site for Jnm1/Dynamitin and Nip100/p150<sup>Glued</sup>
Molecular Biology of the Cell·2005· 12 citedOpen Access
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm
Proceedings of the National Academy of Sciences·2002· 65 citedOpen Access
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Frequent Co-authors

Richie Khanna(7), Karen Kozarsky(6), Lee Pellegrino(5), David J. Lockhart(5), Nastry Brignol(5), David I. Meyer(4), Rick Hamler(4), Michelle Frascella(4), Kenneth J. Valenzano(4), Carrie Ng(4), Casey A. Maguire(4), Vidyullatha Vasireddy(4), Brian Ranes(3), Brandon A. Wustman(3), Leo B. Dungan(3), Elfrida R. Benjamin(3), Robert E. Boyd(3), J. M. Yochim(3), Yi Gong(3), John J. Flanagan(2)