John D. Graef

Sarepta Therapeutics (United States) — United States

Neuroscience · Life Sciences

13h-index957citations30works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(12), Ion channel regulation and function(8), Receptor Mechanisms and Signaling(6), Nicotinic Acetylcholine Receptors Study(6), Genetics and Neurodevelopmental Disorders(5)

Publications30 total

AAV-based CRISPR-Cas9 genome editing: Challenges and engineering opportunities
Current Opinion in Biomedical Engineering·2023· 12 cited
Elevated α-synuclein attenuates phagocytosis in <i>SNCA</i> triplication human iPSC-derived neuron:microglia co-cultures
2022· 2 citedOpen Access
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
European Journal of Neuroscience·2019· 42 citedOpen Access
Author response for "Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons"
2019
Author response for "Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons"
2019
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
2019· 3 citedOpen Access
Characterization of pathology-inducing α-synuclein species from human diseased brain tissue
2019· 1 citedOpen Access
Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na<sub>V</sub>1.7 Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2019· 1 cited
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na<sub>V</sub>1.7 Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2018· 28 citedOpen Access
Abstract 241: In Vitro Disease Modeling and Discovery of Small Molecules for the Treatment of Duchenne Muscular Dystrophy Utilizing Patient iPSC-derived Cardiomyocytes
Circulation Research·2018
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
Cell·2018· 488 citedOpen Access
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-D-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Journal of Pharmacology and Experimental Therapeutics·2017· 17 citedOpen Access
Development of New Benzenesulfonamides As Potent and Selective Na<sub>v</sub>1.7 Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2017· 36 citedOpen Access
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor
European Journal of Pharmacology·2017· 17 cited
Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays
Journal of Neurophysiology·2016· 60 citedOpen Access
Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus
Brain Research·2015· 45 cited
TC-8831, a nicotinic acetylcholine receptor agonist, reduces l-DOPA-induced dyskinesia in the MPTP macaque
Neuropharmacology·2013· 38 cited
Slice XVIvo™: A novel electrophysiology system with the capability for 16 independent brain slice recordings
Journal of Neuroscience Methods·2012· 5 cited
Ethosuximide Reduces Ethanol Withdrawal–Mediated Disruptions in Sleep‐Related<scp>EEG</scp>Patterns
Alcoholism Clinical and Experimental Research·2012· 11 citedOpen Access
Validation of a High-Throughput, Automated Electrophysiology Platform for the Screening of Nicotinic Agonists and Antagonists
SLAS DISCOVERY·2012· 11 citedOpen Access
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Frequent Co-authors

Angela Cacace(6), Dwayne W. Godwin(6), Rick L. Pieschl(6), Linda J. Bristow(6), Nikolai B. Fedorov(6), Patrick M. Lippiello(6), Merouane Bencherif(6), Hao Wu(5), Rudolf Jaenisch(5), James Herrington(5), Kimberly Newberry(5), Amy Newton(5), Chicheng Sun(5), Deena Qadir(5), Kimberly Jesseman(5), Lisa Benson(5), Eric Shields(4), Carrie Ng(4), Stephen T. Warren(4), Owen B. Wallace(4)