Karl Box

East Sussex County Council — United Kingdom

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

29h-index3.6kcitations71works0.32yr avg
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Research Topics

Drug Solubulity and Delivery Systems(34), Crystallization and Solubility Studies(29), Analytical Chemistry and Chromatography(23), Chemical and Physical Properties in Aqueous Solutions(14), Drug Transport and Resistance Mechanisms(9)

Publications71 total

Predicting Food Effect On Oral Drug Absorption For Solubility-Epithelial Membrane Permeation-Limited Cases With Bile Micelle Solubilization
Pharmaceutical Research·2025Open Access
Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations
European Journal of Pharmaceutical Sciences·2024· 1 citedOpen Access
A Study of the Particle Drifting Effect Using in Vitro Dissolution Absorption Experiments: Relevance to Clinical Oral Drug Absorption
SSRN Electronic Journal·2024Open Access
Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations
European Journal of Pharmaceutical Sciences·2023· 8 citedOpen Access
Biorelevant Dissolution of Dipyridamole and Piroxicam Using an Automated UV/Vis Spectrophotometric and Potentiometric Dissolution Testing Platform
Dissolution Technologies·2023· 1 citedOpen Access
Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five
Drug Discovery Today·2022· 57 citedOpen Access
On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state
Journal of Drug Delivery Science and Technology·2021· 5 citedOpen Access
On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state
European Journal of Pharmaceutical Sciences·2021· 17 citedOpen Access
Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration
Journal of Pharmacy and Pharmacology·2021· 12 citedOpen Access
Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number
Journal of Pharmaceutical Sciences·2020· 9 citedOpen Access
Novel Biphasic Lipolysis Method To Predict <i>in Vivo</i> Performance of Lipid-Based Formulations
Molecular Pharmaceutics·2020· 25 cited
On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development
Pharmaceutics·2020· 28 citedOpen Access
Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state
European Journal of Pharmaceutical Sciences·2020· 20 cited
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
European Journal of Pharmaceutical Sciences·2019· 29 cited
Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance
European Journal of Pharmaceutical Sciences·2019· 21 cited
Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects
European Journal of Pharmaceutics and Biopharmaceutics·2019· 26 cited
Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review
Journal of Pharmacy and Pharmacology·2018· 19 citedOpen Access
<i>In vitro</i> methods to assess drug precipitation in the fasted small intestine – a PEARRL review
Journal of Pharmacy and Pharmacology·2018· 63 citedOpen Access
Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method
European Journal of Pharmaceutical Sciences·2018· 25 cited
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Medicinal Chemistry·2018· 27 cited
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Frequent Co-authors

John Comer(17), Rebeca Ruiz(8), P J O’Dwyer(8), Jennifer Dressman(7), Christos Reppas(7), Alex Avdeef(6), René Holm(6), Krisztina Takács‐Novák(6), Martin Kuentz(6), Edmund Kostewicz(5), Robert Taylor(5), Chara Litou(5), Kin Yip Tam(4), Mark McAllister(4), Gergely Völgyi(4), Elisabeth Bosch(4), Brendan T. Griffin(4), Stefania Beato(3), Anette Müllertz(3), Ruth Allen(3)