Alex Avdeef

Adaptive Design Association — United States

Chemistry · Physical Sciences

60h-index12.8kcitations197works2.32yr avg
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Research Topics

Analytical Chemistry and Chromatography(75), Crystallization and Solubility Studies(64), Chemical and Physical Properties in Aqueous Solutions(36), Computational Drug Discovery Methods(34), Drug Solubulity and Delivery Systems(31)

Publications197 total

Imipramine solubility-pH profiles: self-aggregation vs. common-ion effect
ADMET & DMPK·2025Open Access
Highly increasing solubility of clofazimine, an extremely water-insoluble basic drug, in lipid-based SEDDS using digestion products of long-chain lipids
Journal of Pharmaceutical Sciences·2025· 3 cited
Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH
ADMET & DMPK·2025· 3 citedOpen Access
Aqueous Solubility of Sodium and Chloride Salts of Glycine─“Uncommon” Common-Ion Effects of Self-Titrating Solids
Molecular Pharmaceutics·2025· 2 cited
Supplementary material to: Imipramine solubility-pH profiles: self-aggregation vs. common-ion effect
CER (University of Belgrade, Institute of Chemistry, Technology and Metallurgy)·2025Open Access
Effects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media
Pharmaceutics·2024· 4 citedOpen Access
Supersolubilization and Amorphization of a Weakly Acidic Drug, Flurbiprofen, by applying Acid-Base supersolubilization (ABS) principle
International Journal of Pharmaceutics·2024· 11 cited
Predicting Solubility of New Drugs
2024· 4 cited
Predicting Solubility of New Drugs
2024· 1 cited
Predicting Solubility of PROTACs
2024
Solubility Prediction Methods
2024
Physicochemical Properties of Wiki-pS0 Database Molecules
2024
A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts
European Journal of Pharmaceutical Sciences·2023· 5 citedOpen Access
Mechanistically transparent models for predicting aqueous solu¬bility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression Alex Avdeef
ADMET & DMPK·2023· 2 citedOpen Access
Anomalous salting-out, self-association and pKa effects in the practically-insoluble bromothymol blue
ADMET & DMPK·2023· 3 citedOpen Access
Clofazimine p<i>K</i><sub>a</sub> Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions
Molecular Pharmaceutics·2023· 13 cited
In memoriam - Konstantin Tsinman (1968 - 2020)
ADMET & DMPK·2022Open Access
Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation
ADMET & DMPK·2022· 1 citedOpen Access
Correction: Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021
Journal of Solution Chemistry·2022Open Access
Trends in PhysChem Properties of Newly Approved Drugs over the Last Six Years; Predicting Solubility of Drugs Approved in 2021
Journal of Solution Chemistry·2022· 10 cited
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Frequent Co-authors

Oksana Tsinman(8), Manfred Kansy(6), Per Artursson(6), Kiyohiko Sugano(5), Karl Box(5), John Comer(5), Li Di(4), Bernard Faller(4), Konstantin Tsinman(4), Gerhard F. Ecker(3), Holger Fischer(3), Kin Yip Tam(3), Kenneth N. Raymond(3), Krisztina Takács‐Novák(3), J. Brian Houston(3), Edward H. Kerns(3), Hans Lennernäs(3), Bernard Testa(3), Stefanie Bendels(2), C. Hibbert(2)