James J. Kaminski

Broad Institute — United States

Immunology and Microbiology · Life Sciences

32h-index4.4kcitations160works4.32yr avg
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Research Topics

T-cell and B-cell Immunology(16), Chemical Synthesis and Analysis(15), Immune Cell Function and Interaction(15), CAR-T cell therapy research(14), Synthesis and Reactions of Organic Compounds(12)

Publications160 total

Discovery of the transcription factor ZNF683/hobit as a central regulator of pathogenic T cell proliferation in acute gvhd
Blood·2025Open Access
Combined TCR-seq and single-cell RNA-seq reveal distinct origins for antiviral immunity after post-transplant cyclophosphamide and tac/MTX gvhd prophylaxis: Results from the BMT CTN 1801 study
Blood·2025
Organ-specific microenvironments drive divergent T cell evolution in acute Graft-Versus-Host Disease 3176
The Journal of Immunology·2025Open Access
PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model
2025Open Access
Using single-cell transcriptomics to reveal CD226 upregulation and enhancement of CD19-CAR-T function in the inhibitory CNS microenvironment of refractory CNS lymphoma.
Journal of Clinical Oncology·2025
Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant
2025· 5 citedOpen Access
Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease
Science Translational Medicine·2025· 6 citedOpen Access
A pilot study of axicabtagene ciloleucel (axi-cel) for relapsed/refractory primary and secondary central nervous system lymphoma (PCNSL and SCNSL).
Journal of Clinical Oncology·2024· 17 cited
B-cell–directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates
Blood·2024· 19 citedOpen Access
Enhanced Proliferation and Effector Function in PTPN2 Knockout CAR-T Cells Associated with Toxicities in a Non-Human Primate Model of CD20 CAR-T Cell Therapy
Transplantation and Cellular Therapy·2024
Reshaping of Local Alloimmunity By Organ-Specific Microenvironments during Acute Gvhd.
Transplantation and Cellular Therapy·2024
Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model
Blood·2023· 1 cited
B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients
2023· 1 citedOpen Access
Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd
Transplantation and Cellular Therapy·2023Open Access
CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts
Blood·2022· 1 cited
Targeting CNS Lymphoma with Intravenous Axicabtagene Ciloleucel: Evidence for Transcriptional Evolution Towards a Prominent Interferon Signature in CAR-T Cells Trafficking to the Tumor Site
Blood·2022· 4 cited
Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd
Blood·2022· 4 cited
Batf-mediated epigenetic control of effector CD8 <sup>+</sup> T cell differentiation
Science Immunology·2022· 57 cited
Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform
Frontiers in Immunology·2022· 9 citedOpen Access
CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels
Cell Reports·2022· 34 citedOpen Access
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Frequent Co-authors

Nicholas Bodor(12), Daniel M. Solomon(7), Nir Yosef(5), Arthur J. Elliott(5), David J. Conn(5), Nicolae Bodor(5), Marcus E. Brewster(5), Ulrike Gerdemann(4), Raymond G. Lovey(4), Henry Guzik(4), Shing Chun Wong(4), Takeru Higuchi(4), Sally H. Selk(3), Andrew T. McPhail(3), Razia Rizvi(3), P. J. S. Chiu(3), Leslie S. Kean(3), R. Anthony Barnitz(2), Makoto Kurachi(2), Hsiao‐Wei Tsao(2)