Lauren G. Zacharias

The University of Texas Southwestern Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.2kcitations85works3.22yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(44), Metabolism, Diabetes, and Cancer(20), Cancer, Lipids, and Metabolism(13), Epigenetics and DNA Methylation(12), Lung Cancer Treatments and Mutations(9)

Publications85 total

Characterizing the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer’s brains
2026Open Access
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Science·2025Open Access
TMET-32. Cell-intrinsic pyrimidine synthesis pathway choice in human brain and glioma
Neuro-Oncology·2025Open Access
TMET-27. Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis
Neuro-Oncology·2025Open Access
TMET-34. A Targetable Metabolic Signal Drives Neuronal Hyperexcitability and Glioma Aggressiveness
Neuro-Oncology·2025Open Access
TMET-47. N-acetylcysteine induced lactate reprogramming is a targetable metabolic susceptibility in glioblastoma
Neuro-Oncology·2025
Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment
Neuro-Oncology·2025· 2 citedOpen Access
Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors
2025Open Access
Compositionally Distinct Renal Lipid Droplets Form in Response to Different Stimuli
Journal of the American Society of Nephrology·2025
Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth
2025Open Access
Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis
2025· 1 citedOpen Access
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
Nature Metabolism·2025· 3 citedOpen Access
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice
2025· 1 citedOpen Access
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
Journal of Clinical Investigation·2025· 1 citedOpen Access
Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate
Proceedings of the National Academy of Sciences·2025· 6 citedOpen Access
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of <i>MYC</i> expression
2025Open Access
A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
2025
Supplementary Figure 2 from High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
2025Open Access
Supplementary Table 4 from High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
2025Open Access
Supplementary Figure 4 from High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
2025Open Access
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Frequent Co-authors

Ralph J. DeBerardinis(39), Thomas P. Mathews(26), Feng Cai(15), Wen Gu(14), Brandon Faubert(13), Hieu Vu(13), Ling Cai(11), Misty S. Martin-Sandoval(10), Chendong Yang(9), Panayotis Pachnis(9), Min Ni(8), Ashley Solmonson(8), Diana D. Shi(8), Yi Xiao(8), Kalil G. Abdullah(8), Samuel K. McBrayer(8), Akash Kaushik(7), Milan R. Savani(7), Aparna D. Rao(7), Jessica Sudderth(7)