Elias Lolis

Yale Cancer Center — United States

Immunology and Microbiology · Life Sciences

45h-index8.5kcitations174works2.12yr avg
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Research Topics

Macrophage Migration Inhibitory Factor(97), Nuclear Receptors and Signaling(41), Chemokine receptors and signaling(22), Monoclonal and Polyclonal Antibodies Research(10), Enzyme Structure and Function(10)

Publications174 total

A crystal structure of DUSP10 loop mutant I445A
2025
Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
Nature Communications·2025· 1 citedOpen Access
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia
ACS Omega·2025Open Access
In vivo synergistic enhancement of <scp>MIF</scp> ‐mediated inflammation in acute lung injury by the plant ortholog <i>Arabidopsis</i> <scp>MDL1</scp>
The FASEB Journal·2025· 1 citedOpen Access
Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
2024· 3 citedOpen Access
A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus
Journal of Biological Chemistry·2024· 5 citedOpen Access
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
Molecular Medicine·2024· 5 citedOpen Access
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells
Science Signaling·2023· 4 citedOpen Access
Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase
Journal of Biological Chemistry·2023· 8 citedOpen Access
Supplementary Table 1 from A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells
2023Open Access
Supplementary Table 1 from A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells
2023Open Access
Data from A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells
2023Open Access
Data from A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells
2023Open Access
Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases
Biophysical Journal·2023· 1 citedOpen Access
Structures of <i>Arabidopsis thaliana</i> MDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors
2023Open Access
Progress and challenges with therapeutic targeting of chemokine receptors
Frontiers research topics·2023
Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism
Computational and Structural Biotechnology Journal·2023· 5 citedOpen Access
A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding
Journal of Biological Chemistry·2022· 9 citedOpen Access
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM
Journal of Structural Biology·2022· 10 citedOpen Access
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors
European Journal of Medicinal Chemistry·2022· 7 citedOpen Access
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Frequent Co-authors

Richard Bucala(16), Lin Leng(14), Yoonsang Cho(7), Jodi B. Lubetsky(7), Jürgen Bernhagen(6), Richard Bucala(6), Swen Zierow(6), G.V. Crichlow(6), Xin Du(5), Georgios Pantouris(5), Robert A. Mitchell(4), Gregory A. Petsko(4), Yibang Chen(4), Jon J. Vermeire(4), Michael Cappello(4), Chengpeng Fan(4), Mansoor Ali Syed(4), Deepa Rajasekaran(4), Vineet Bhandari(4), James W. Murphy(3)