Detlef Obal

University of Iowa — United States

Medicine · Health Sciences

23h-index1.8kcitations65works7.02yr avg
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Research Topics

Cardiac Ischemia and Reperfusion(27), Anesthesia and Neurotoxicity Research(20), Cardiac Arrest and Resuscitation(12), Anesthesia and Sedative Agents(11), Cardiac Imaging and Diagnostics(7)

Publications65 total

Pro-Con Debate: Opioids and Perioperative Organ Injury—Friend or Foe?
Anesthesia & Analgesia·2025
Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization
Science·2025· 33 citedOpen Access
Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production
Scientific Reports·2025· 2 citedOpen Access
Opioid Preconditioning in Heart Failure: New Frontier or Old Dog?
Anesthesia & Analgesia·2025
Cardioprotection by Poloxamer 188 is Mediated through Increased Endothelial Nitric Oxide Production
2024Open Access
Abstract 195: Dose-Dependent Induction of Nitric Oxide Production in Human Induced Pluripotent Stem Cell-Derived Endothelial Cells by Poloxamer 188
Circulation·2023
Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension
Stem Cell Research·2023· 1 citedOpen Access
Detecting and measuring of GPCR signaling – comparison of human induced pluripotent stem cells and immortal cell lines
Frontiers in Endocrinology·2023· 2 citedOpen Access
Nasopharyngeal Ventilation Compared to Facemask Ventilation: A Prospective, Randomized, Crossover Trial in Two Different Elective Cohorts
Cureus·2023· 3 citedOpen Access
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling
EMBO Molecular Medicine·2022· 29 citedOpen Access
Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization
2022· 14 citedOpen Access
Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart
Journal of the American Heart Association·2022· 11 citedOpen Access
Abstract 11110: Triomic Approach Reveals the Metabolic, Genomic and Proteomic Influences of the Endogenous Histidyl Dipeptides on Heart
Circulation·2021
Multiomics reveals the genomic, proteomic and metabolic influences of the histidyl dipeptides on heart
2021Open Access
Healthy obese
Oxford University Press eBooks·2021
Induced pluripotent stem cells as a platform to understand patient‐specific responses to opioids and anaesthetics
British Journal of Pharmacology·2020· 8 citedOpen Access
Is Fresh Frozen Plasma Still Necessary for Management of Acute Traumatic Coagulopathy?
Current anesthesiology reports·2020· 2 cited
Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury
Journal of the American Heart Association·2020· 46 citedOpen Access
Perioperative analgesic administration during the 2018 parenteral opioid shortage in the United States – A retrospective analysis
Journal of Clinical Anesthesia·2020
A Guide to Understanding “State-of-the-Art” Basic Research Techniques in Anesthesiology
Anesthesia & Analgesia·2020· 3 citedOpen Access
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Frequent Co-authors

W. Schlack(22), Benedikt Preckel(19), V. Thämer(11), Jost Müllenheim(9), Aruni Bhatnagar(7), Horst Scharbatke(6), Holger Barthel(6), Daniel J. Conklin(6), Joseph C. Wu(6), S. Dettwiler(4), Octavian Toma(4), Gregg Rokosh(4), Yiru Guo(4), Roberto Bolli(4), Marc Heiderhoff(4), C. Favoccia(3), Nina C. Weber(3), J. I. Wolter(3), Kartik Katragadda(3), Bradford G. Hill(3)